侵袭性牙周炎治疗前后龈沟液CRP、sICAM-1含量测定被引量：15

The study of nonsurgical periodontal therapy on C-reactive protein and soluble intercellular adhesion molecule-1 levels of the gingival crevicular fluid with aggressive periodontitis.

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摘要目的:测定侵袭性牙周炎龈沟液中C反应蛋白、可溶性细胞间黏附分子1的含量及牙周非手术治疗对其水平的影响,方法:16例侵袭性牙周炎病例,进行非手术治疗,收集治疗前后龈沟液,用酶联免疫吸附法(ELISA法)测定C反应蛋白(CRP)、可溶性细胞间黏附分子(1sICAM-1)水平,并和正常对照组比较。结果:侵袭性牙周炎患者龈沟液中CRP、sICAM-1水平增高,和对照组比较,p<0.05;牙周非手术治疗后,牙周临床指标明显改善,龈沟液中CRP、sICAM-1水平下降,且接近牙周正常水平。结论:侵袭性牙周炎龈沟液CRP、sICAM-1的水平升高,牙周非手术治疗能有效降低CRP、sICAM-1在龈沟液中的表达。 Objective： The aim of the present study was to determine whether the presence of aggressive periodontitis and subsequent periodontal therapy could influence the gingival crevicular fluid （GCF） lovels of C-reactive protein （CRP） and soluble intercellular adhesion molecule-1 （sICAM-1）.Method： GCF was obtained from 16 patients with aggressive periodontitis at the baseline examination and reassessment after completion of the treatment. As a control, GCF was also obtained from 16 subjects without periodontitis. CRP and sICAM-1 were determined by sensitive enzyme-linked immunosorbent assay.Result： The levels of CRP and sICAM-1 in the GCF of aggressive periodontitis was higher than that in health control subjects. Periodontal status demonstrated a significant improvement in all patients following the treatment. CRP and sICAM-1 concentration was reduced significantly with improvement of the periodontal condition following treatment and approached that of control subjects.Conclusion： In this study, we were able to show that periodontitis disease significantly affects the levels of CRP and sICAM-1 in the GCF.

作者罗志晓陈睿解晓琴周作华

机构地区郧阳医学院附属太和医院口腔科郧阳医学院附属太和医院检验科

出处《临床口腔医学杂志》 2006年第10期590-591,共2页 Journal of Clinical Stomatology

关键词侵袭性牙周炎 C反应蛋白可溶性细胞间黏附分子1 龈沟液 aggressive periodontitis CRP sICAM-1 GCF

分类号 R781.4 [医药卫生—口腔医学]

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