摘要
目的:探讨舌癌患者颈部阴性淋巴结中的微转移与临床病理因素的关系及对预后的影响。方法:对60例舌癌患者经常规病理检查为阴性的淋巴结,采用免疫组化结合连续切片方法行微转移检测,χ2检验用于检验各临床病理因素与微转移之间的关系,Kaplan-Meier曲线用于描述有、无微转移2组患者的生存曲线分布,Logrank检验用于分析两者之间有无显著性差异,Cox回归用于分析包括微转移在内的各临床病理因素是否为影响预后的独立因素。结果:临床病理因素(年龄、性别、pT分期、肿瘤分级、原发灶浸润深度)与微转移之间无显著相关性(Ρ>0.05);有微转移和无微转移2组患者的3年生存率分别为77.7%和86.0%,无显著性差异(Ρ=0.235)。结论:微转移与临床病理因素之间无显著相关性,包括微转移在内的临床病理因素不能作为影响舌癌预后的独立因素。
PURPOSE： To analyse the relations between micrometastases and clinicopathological factors and to determine the influence on prognosis in tongue cancer with histopathological negative nodes. METHODS： A method combined with IHC and serial sectioning was used to detect the micrometestases of negative lymph node by routine histological examination of 60 patients with tongue cancer. The relationship between clinicopathological type and micrometastases was detected with a Chi-square test .The equality of survival curves was assessed with Log rank test.Cox＇ proportional hazard model was used to identify whether the clinicopathological factors,including micrometastases were independently associated with prognosis of tongue cancer. RESULTS： There were no statistically significant correlations between micrometastases and the clinicopathological features as follows： sex, age, pT stage,grade of differentiation,depth of primary tumor invasion （P〉0.05）. The 3-year survival rates of patients with and without micrometastases were 77.7% and 86.0%,no statistically significant correlations were noted （P=0.235）. CONCLUSIONS： Micrometastases and clinicopathological factors have no significant correlations and they are not independent prognostic factors in tongue cancer.
出处
《中国口腔颌面外科杂志》
CAS
2006年第5期341-344,共4页
China Journal of Oral and Maxillofacial Surgery
关键词
舌癌
微转移
病理学
预后
Tongue cancer
Micrometastases
Pathology
Prognosis
