摘要
目的:本研究主要目的为确定直肠癌的淋巴结转移的危险因素。方法:通过对1250例于2004年-2008年行直肠癌根治性切除的患者进行单因素和多因素分析,以确定淋巴结转移相关的危险因素,同时对PT分期和肿瘤大小之间的关系进行了相关性分析。结果:直肠癌患者淋巴结转移发生率为41%。在单因素分析中,患者年龄(P=0.008)、肿瘤大小(P=0.003)、PT分期(P<0.0019)以及分化程度(P<0.001)和淋巴结转移相关。在多因素分析中,年龄(P=0.017,OR=0.988,95%可信区间:0.978-0.998)、PT分期(P<0.001,OR=1.952,95%可信区间:1.656-2.302)和分化程度(P<0.001,OR=3.697,95%可信区间:2.112-6.472)是淋巴结转移的独立因素。结论:在直肠癌相关分析中,肿瘤的大小和PT分期呈正相关。年龄、PT分期和肿瘤分化程度是淋巴结转移的独立因素。在直肠癌中,肿瘤的大小和PT分期呈正相关。
Objective： To identify risk factors of lymph node metastasis in rectal cancer.Methods： Data from 1250 patients with rectal cancer who underwent radical resection from 2004 to 2008.Univariate and multivariate analysis were performed to identify risk factors associated with lymph node metastasis.The relationship between pT stage and tumor size was analyzed by correlate analysis.Results： The incidence of lymph node metastasis was 41.0% for patients with rectal cancer.In the univariate analysis,age（P=0.008）,tumor size（P=0.003）,pT stage（P0.001） and differentiation（P0.001） were correlated with LNM.In multivariate analysis,only age（P=0.017,OR=0.988,95% confidence interval（CI）： 0.978-0.998）,pT stage（P0.001,OR=1.952,95% CI： 1.656-2.302） and differentiation（P0.001,OR=3.697,95% CI： 2.112-6.472） were independent factors for lymph node metastasis.A positive association was found between tumor size and pT stage by correlate analysis in rectal cancer.Conclusion： Age,pT stage and differentiation might be predictive factors for lymph node metastasis.Tumor size and pT stage had positive correlation in rectal cancer.
出处
《现代生物医学进展》
CAS
2012年第16期3107-3111,共5页
Progress in Modern Biomedicine
基金
supported in part by department of pathology of Liao Ning Tumor Hospital,Shenyang,China
关键词
淋巴结转移
直肠癌
危险因素
Lymph node metastasis
Rectal cancer
Risk factors
