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细胞凋亡与凋亡诱导因子 被引量：17

Apoptosis and apoptosis-inducing factor
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摘要 [A Review] The process of apoptosis is very complex.Apoptosis-inducing factor(AIF)has the ability to induce apoptosis via a caspase-independent pathway.The mature AIF protein,a flavoprotein(prosthetic group:flavine adenine dinucleotide)is normally confined to the mitochondrial intermembrane space.AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus.AIF induces nuclear chromatin condensation,as well as large scale(V50 kb)DNA fragmentation.AIF is a phyloge-netically old,bifunctional protein with an electron acceptor/donor(oxidoreductase)function and a second apoptogenic function and AIF acts in a caspase-independent fashion.The molecular mechanisms via which AIF induces apoptosis are discussed in this review. The process of apoptosis is very complex. Apoptosis - inducing factor （AIF） has the ability to induce apoptosis via a caspase - independent pathway. The mature AIF protein, a flavoprotein （ prosthetic group ： flavine adenine dinucleotide） is normally confined to the mitochondrial intermembrane space. AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus. AIF induces nuclear chromatin condensation, as well as large scale （ VSO kb ） DNA fragmentation. AIF is a phyloge - netically old, bifunctional protein with an electron acceptor/donor （ oxidoreductase ） function and a second apoptogenic function and AIF acts in a caspase -independent fashion. The molecular mechanisms via which AIF induces apoptosis are discussed in this review.
作者 张闻多 丁文惠
机构地区 北京医院心内科 北京大学第一医院心内科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2006年第9期1858-1862,共5页 Chinese Journal of Pathophysiology
基金 首都医学发展科研基金资助(No. 2002 -2003)
关键词 细胞凋亡 凋亡诱导因子 Apoptosis Apoptosis - inducing factor
分类号 R363 [医药卫生—病理学]
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参考文献29

  • 1De Jong D,Prins FA,Mason DY,et al.Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells[J].Cancer Res,1994,54 (1):256-260.
  • 2Nicholas J,Santos AS,Eric D,et al.Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death[J].Nature,2001,410(6828):549-554.
  • 3Susin SA,Lorenao HK,Zamzami N,et al.Molecular characterization of mitochondrial apoptosis-inducing factor[J].Nature,1999,67(18):441-446.
  • 4Loeffler M,Daugas E,Susin SA,et al.Dominant cell death induction by extra mitochondrially targeted apoptosis inducing factor[J].FASEB J,2001,15(3):758-767.
  • 5Céline C,Isabelle C,Eric D,et al.Apoptosis-inducing factor (AIF):a novel caspase-independent death effector released from mitochondria[J].Biochimie,2002,84 (2-3):215-222.
  • 6Lorenzo HK,Susin SA,Penninger J,et al.Apoptosis-inducing factor (AIF):a phylogenetically old,caspase-independent effector of cell death[J].Cell Death Differ,1999,6(6):516-524.
  • 7Maria JM,Miguel OL,Brigette B,et al.The crystal structure of the mouse apoptosis-inducing factor AIF[J].Nature,2002,9 (6):442-446.
  • 8Wu M,Xu L,Li X,et al.AMID,an apoptosis-inducing factor homologous mitochondrion associated protein induces caspase-independent apoptosis[J].Biol Chem,2002,277 (28):25617-25623.
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二级参考文献11

  • 1[1]Susin S A, Lorenao H K, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis inducing factor.Nature, 1999, 397 (6718): 441～446
  • 2[2]Daugas E, Susin S A, Zamzami N, et al. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J, 2000, 14(5): 729～739
  • 3[3]Leoffler M, Daugas E, Susin S A, et al. Dominant cell deathinduction by extramitochondrially targeted apoptosis-inducing factor. FASES J, 2001, 15 (3): 758～767
  • 4[4]Joza N, Susin S A, Daugas E, et al. Essential role of the mitochondrial apoptosis-inducing factor in progranmed cell death.Nature, 2001, 410 (6828): 549～554
  • 5[5]Susin S A, Daugas E, RavagnanL, et al. Two distinct pathways leading to nuclear apoptosis. J Exp Med, 2000, 192 (4): 571～579
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  • 10[10]Lorenzo H K, Susin S A, Penninger J, et al. Apoptosis inducing factor (AIF): a phylogenetically old, caspaac-independent effector of cell death. Cell Death Differ, 1999, 6 (6): 516～524

共引文献9

同被引文献211

引证文献17

二级引证文献91

中国病理生理杂志
2006年 第9期

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