摘要
目的观察改良法深低温保存的同种带瓣主动脉临床使用的长期效果并对该保存方法进行评价。方法30例法洛四联症病人分为两组，A组病人肺动脉功能发育良好，B组病人肺动脉发育不良。使用1989～1997年采用改良两步法深低温保存的同种活性带瓣主动脉标本（平均保存时间289d），行右室流出道重建术，临床使用6～12年后，应用心脏超声观察其反流、狭窄和钙化的情况。结果A组15例病人中肺动脉反流1例，肺动脉狭窄1例；B组15例病人中肺动脉反流3例，肺动脉狭窄1例，三尖瓣反流1例。30例病人超声检查显示同种血管及瓣膜均无钙化，活动良好。结论改良两步法保存的带瓣主动脉临床应用具有良好的远期效果。
Objective To evaluate the long-term effect of cryopreserved homograft aortic valves by modified two-step method. Methods Thirty patients with tetralogy of FALLOT （TOF） were divided into two equal groups. The patients in group A had a normal pulmonary valve function while those in group B had a poor pulmonary valve function. The homograft aortic valvular patches used were cryopreserved during 1989-1997 by modified two-step method and the average storage time was 289 days. All the patches were used to reconstruct the right ventricular outflow tracts in children with TOF. The regurgitation, constriction, and calcification were assessed by heart-ultrasonography. Results In group A, pulmonary reflow （PR） occurred in one patient and pulmonary stenosis （PS） in another one. In group B, PR occurred in three patients, PS in one and tricuspid regurgitation （TR） in one. No calcification was found and homograft aortic valves functioned well. Conclusion The homograft aortic valves cryopreserved by modified two-step method have a good long-term effect in clinical application.
出处
《齐鲁医学杂志》
2006年第4期315-316,318,共3页
Medical Journal of Qilu
关键词
同种带瓣主动脉
二甲亚砜
深低温保存
法洛四联症
homograft aortic valves
dimethyl sulfoxide
cryopreservation
tetralogy of FALLOT
