摘要
目的检测PIG11(p53-induced gene 11)蛋白在人体正常组织及其相应肿瘤组织中的表达情况,探讨PIG11蛋白在人体正常组织的分布特点,及在肿瘤发生发展中所起的作用。方法利用免疫组化SP法检测PIG11蛋白在319例人体正常组织及其相应肿瘤组织中的表达。结果PIG11蛋白在胃、肠、肝、乳腺等腺上皮及鳞状上皮组织中明显表达阳性,在正常胃黏膜腺颈部较体部和底部表达降低。在纤维、脂肪、平滑肌、淋巴组织及脑组织中无明显表达。PIG11蛋白在肝癌、低分化胃和肠腺癌、乳腺癌组织中较相应正常组织均有明显表达下调(P<0.01);在鳞癌组织中,与正常鳞状上皮比较,也有表达下调(P<0.05)。结论PIG11蛋白主要分布在人体上皮组织,且与细胞的分化程度有关;PIG11蛋白低表达与上皮源性的恶性肿瘤发生发展有关。
Objective To investigate the expression of PIG11 （p53 - induced gene 11 ）protein in human norreal tissue and corresponding tumor tissue, discussing the distributing characteristic of PIG11 protein in human norreal tissue and its function in the tumorigenesis and development. Methods The expression of PIG11 protein in 319 cases of humall normal tissues and conesponding tumor tissues was determined by immunohistoehemical peroxidase- conjugated streptavidin （SP） method. Results The expression of PIG11 protein was positive in human gastric mucosa, intestine mucosa, liver, galactophore glandular epithelium, and squamous epithelium tissue. Expression of PIG11 protein in cervical part of normal gastric mucosa gland was lower than that of candomedial part and bottom. Its expression was negative in human fibre, fat tissue, smooth muscle, lymph tissue and brain tissue. Exsion of PIG11 protein is involved in cellular differentiation. Down - regulation of PIG11 protein is connected with tumorigcnesis and development in epidermic malignant tumors.
出处
《南华大学学报（医学版）》
2006年第2期176-180,共5页
Journal of Nanhua University(Medical Edition)
