摘要
目的：研究实验室合成的三价铁制剂对贫血模型小鼠的影响。方法：测试高铁制剂的理化性质，检测其毒性及对贫血模型小鼠Hb的影响。结果：高铁制荆蒸馏水溶液和生理盐水溶液清澈透明，pH4～11无沉淀，有较好的生物利用度。急性毒性实验，说明高铁制荆无毒或毒性极小。对贫血模型小鼠补铁后，通过比较实验组与阳性、阴性对照组Hb的OD380值，反映出实验组Hb的浓度恢复情况较好，证明高铁制剂对缺铁性贫血症有一定的补血作用。结论：高铁制剂有望成为良好的新型生物补铁剂。
Objective：Study the impact on mice of anemian model of Iron（ Ⅲ） - preparation. Method： The physico- chemical property, efficacy and toxicity of Iron（ Ⅲ） - preparation were examined in this paper. Result： No precipitates were found at pH scale ranging from 4 to 11. Compared the OD value between controlling groups and experimental groups, the concentration of Hb of the experimental groups resume better, so the Iron（Ⅲ ） - preparation shows greatly efficacy. Through the acute toxicity exam, it was proved that Iron （Ⅲ） - preparation had little or no toxicity. Conclusion： Iron（ Ⅲ ） - preparation was able to have better bioavailability as an iron supplement.
出处
《微量元素与健康研究》
CAS
2006年第5期1-3,共3页
Studies of Trace Elements and Health
基金
山西省科技攻关项目(041149)
山西省青年科技研究基金(20021037)
山西省教育厅产业化项目和太原市启明星计划
关键词
高铁制剂
贫血
急性毒性
Iron（ Ⅲ） - preparation
Anemia
Acute toxicity
