摘要
目的:探讨p27、bcl-2、Ki-67在胃肠道间质瘤(GIST)的表达及其意义。方法:采用免疫组化二步法检测57例GIST患者中p27、bcl-2、Ki-67、CD117、CD34的表达。结果:本组57例GIST中p27阳性率为53％,bcl-2阳性率为58％,Ki-67阳性率为40％。良性、交界性、恶性GIST组中p27阳性表达率降低(P<0．05),Ki-67阳性表达率增高(P<0．05),bcl-2阳性表达率有增高的趋势(P=0．07)。p27与bcl-2、p27与Ki-67两者之间均具有相关性(P<0．05)。57例GIST中CD117阳性率为83％,CD34阳性率为75％,CD117和CD34均为阳性36例(63％),14例CD34阴性病例CD117均为阳性。良性、交界性、恶性GIST组中CD117阳性表达率、CD34阳性表达率差别均无显著性。结论:p27、bcl-2、Ki-67联合检测可作为预测GIST恶性潜能一项参考指标;CD117和CD34联合检测是诊断GIST重要的参考指标。
Objective： To explore the expression of p27, bcl - 2 and Ki - 67 and their relationships in gastrointestinal stromal tumor.Methods： The expression of p27, bcl - 2, Ki - 67, CD117 and CD34 were detected by Ehvision immunohistechemistry.Results：The positive expression of p27 was 53%, bcl - 2 was 58%, Ki - 67 was 40%. p27 was expressed significantly lower in bordline tuomors and malignant groups （P 〈 0.05）. bcl - 2 and Ki - 67 were adversely expressed higher in bordhne tuomors malignant groups （P 〈 0.05）. The positive expression of CD117 was 83%, CD34 was 75%. All 14 cases negtive of CD34 were positive of CD 117. But there were no significance of CD 117 and CD34 among three groups （P 〉 0. 05）. Conclusion： The abnormal expression of p27, bcl - 2 and Ki - 67 can be used as biological figures for predicting malignant progression. CD117 and CD34 might be potential markers in diagnoses for GIST.
出处
《中国医药导刊》
2006年第4期242-244,共3页
Chinese Journal of Medicinal Guide
