摘要
目的 研究胃肠道间质瘤中nm2 3和增殖细胞核抗原 (PCNA)的表达。方法 采用免疫组织化学SP法对胃肠道间质瘤进行研究 ,并对所有病例进行了随访。结果 6 5例胃肠道间质瘤nm2 3蛋白阳性率分别为 :良性 90 .9%(2 0 / 2 2 )、潜在恶性 89.3% (2 5 / 2 8)、恶性 80 .0 % (12 / 15 ) ;三者两两相比较 ,差异均无显著性 (P >0 .0 5 ) ;恶性组nm2 3阳性率 :有转移的为 85 .7% (6 / 7) ,无转移的为 75 .0 % (6 / 8) ,两者比较 ,差异无显著性 (P >0 .0 5 ) ;6 5例PCNA平均标记指数分别为 :良性 34.5 %、潜在恶性 6 2 .3%、恶性 88.7% ;三者两两相比较 ,差异均有显著性 (P <0 .0 5 )。转移组PCNA指数为 95 .4 % ,无转移组PCNA指数为 73.6 % ,二者比较 ,差异有显著性 (P <0 .0 5 )。结论 nm2 3蛋白检测无助于判断胃肠道间质瘤的良恶性及预测预后 ;检测PCNA有助于判断胃肠道间质瘤的良恶性及预测预后。
Objective To study the significance of nm23 protein and PCNA expression in gastrointestinal stromal tumors (GISTs). Methods The expression of nm23 protein and PCNA was investigated by SP immunohistochemical technique in 65 cases of GISTs. Results The positive expression of nm23 protein in benign, potentially malignance and malignance were 90.9%, 89.3% , and 80.0% respectively, there was no significant difference among the groups. The positive expression of PCNA in benign, potentially malignance and malignance were 34.5%, 62.3%, and 88.7% respectively, there was a significant difference among the groups. There was a positive correlation between PCNA expression and lymph node metastasis in GISTs. Conclusions The expression of PCNA is an important predicting marker for prognosis of GISTs, but nm23 protein is not.
