摘要
目的:探讨了鼻咽癌患者放疗前后血清TNF-α、β2-m水平的变化及临床意义。方法:应用放射免疫分析对31例鼻咽癌患者进行了血清TNF-α、β2-m水平测定,并与35名正常健康人作比较。结果:鼻咽癌患者在放疗前血清TNF-α、β2-m水平非常显著地高于正常人组(P<0.01),放疗后三个月则与正常人比较无显著性差异(P>0.05)。结论:测定鼻咽癌患者血清中TNF-α、β2-m水平的变化对临床疗效观察和预后判断均有重要的临床意义。
Objective To study the clinical significance of changes of serum TNF -α and β2-m levels after radiation therapy in patients with nasopharyngeal cancer. Methods Serum TNF-α and β2-m levels were measured with RIA in 31 patients with nasopharyngeal cancer both before and after radiation therapy as well as in 35 controls. Results Before radiation therapy the serum TNF -α and β2-m levels in patients were significantly higher than those in the controls （P 〈0.01 ）, Three months after completion of radiation therapy, the serum TNF-α and β2-m levels dropped markedly and were not significantly different from those in controls （P 〉0. 05 ）. Conclusion Changes of serum TNF-α and β2-m contents after radiation therapy might be of prognostic value in patients with nasopharyngeal cancer.
出处
《放射免疫学杂志》
CAS
2006年第4期295-296,共2页
Journal of Radioimmanology
