摘要
目的观察丹参对脑出血病人血管内皮功能的影响及意义。方法52例中小量高血压脑出血病人随机分为丹参组(治疗组)和对照组,另选年龄、身高、体重相匹配的单纯高血压病病人20例作为高血压组。用酶联免疫吸附试验法(ELISA)检测脑出血病人治疗前后及单纯高血压病病人6-酮-前列腺素F1α(6-keto-PGF1α)和血管性假血友病因子(vWF)水平。结果脑出血病人血浆vWF水平显著高于高血压组,而6-keto-PGF1α显著低于高血压组(P<0.01);脑出血病人治疗后,治疗组vWF水平显著低于对照组,6-keto-PGF1α显著高于对照组,血肿周围水肿带的改善优于对照组。结论脑出血病人出现明显的血管内皮功能障碍,丹参对血管内皮细胞有保护作用,可以减轻脑出血后脑水肿。
Objective To investigate the influence of Danshen injection on vascular endothelium function in patients （pts） with intracerebral hemorrhage. Methods Fifty - two pts with hypertensive cerebral hemorrhage were divided randomly into control group and treatment group, while 20 pts with hypertension were served as the hypertension group. The plasma vWF and 6 - keto - PGF1α were measured by ELISA. Results The level of vWF in the pts with intracerebral hemorrhage was significantly higher than that in the pts in hypertension group. But the plasma level of 6 - keto - PGFI, in the pts with intracerebral hemorrhage was significantly lower than that in the pts in hypertension group（P〈 0.01 ）. Two weeks later, the vWF level in treatment group was significantly lower than that in control group. But The 6 - keto - PGF1α level in treatment group was significantly higher than that in control group; and cerebral edema in the treatment group was significantly better than that in the control group. Conclusion Endothelium damage occurred in pts with hypertensive cerebral hemorrhage. Danshen injection could protect vascular endothelium and decrease cerebral edema.
出处
《中西医结合心脑血管病杂志》
2006年第1期21-22,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
脑出血
血管
内皮功能
丹参
intracerebral hemorrhage
endothelium
Danshen
