摘要
多囊卵巢综合征(PCOS)是育龄妇女常见的生殖内分泌紊乱性疾病,为异质性病变,临床表现各异,其主要内分泌特征为高雄激素血症、高胰岛素血症和胰岛素抵抗、LH水平和LH/FSH比值升高。迄今为止,PCOS的发病机制还不清楚,PCOS患者的高度家族聚集性提示遗传因素在发病中起重要作用,遗传学研究表明影响这些激素代谢和调节的多种基因参与了PCOS的发生发展过程。
Polycystic ovary syndrome （PCOS） is one of the reproductive endocrine disorders which usually affects those wome who are in the reproductive age. The clinical manifestation of PCOS varies, for which it belongs to one of the heterogenous diseases. The main endocrine characteristics of PCOS include hyperandrogenism, hyperinsulinemia, metabolic abnormalities, the increasing level of luteinizing hormone （LH）, and the increasing ratio of LH and follicle -stimulating hormone （FSH） The aetiopathogenesis of this syndrome is not well known so far. The genetic studies show that many genes which influence the metabolism and modulation of these hormones may involve in pathogenesis of PCOS.
出处
《中国优生与遗传杂志》
2006年第8期113-116,共4页
Chinese Journal of Birth Health & Heredity
基金
哈尔滨医科大学研究生创新基金
