摘要
目的：比较甲硝唑片及其缓释药膜在龈沟液中的浓度，以了解其用药差别。方法：１０例典型牙周炎病人分为两组，一组ｐｏ甲硝唑片０．２ｇ，另一组在牙周袋内插入甲硝唑缓释药膜，采用紫外分光光度法，测定龈沟液中甲硝唑的浓度。结果：缓释药膜的用量是片剂的１／４００，而龈沟液中甲硝唑的浓度是片剂的６０倍。结论：甲硝唑在治疗牙周病方面，局部用药的效果明显优于全身用药。
OBJECTIVE:Tocomparetheconcentrationingingivalcrevicularfluidbetweenmetronidazoletabletandsustained-releasefilm.METHOD:Tenperiodontalydiseasedsitesweredividedintotwogroups,onegroupre-ceivedmetronidazole0.2g,theotherinsertedsustained-releasefilmintheirperiodontalpocket.Theultravioletspectrophotometricdeterminationofmetronidazoleingingivalcrevicularfluidwaspresented.RESULTS:Thedoseofsustained-releasefilmwas1/400oftablet,andtheconcentrationingingivalcrevicularfluidwas60times.CON-CLUSION:Metronidazolelocalapplicationintreatingperiodontaldiseaseissignificantlysuperiortothegeneraluse.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1996年第8期486-488,共3页
Chinese Pharmaceutical Journal
关键词
甲硝唑
缓释药膜
龈沟液
牙周炎
gingivalcrevicularfluid,metronidazole,sustained-redleasefilm
