摘要
①目的了解肝癌病人癌与癌旁组织中雄激素受体（ＡＲ）的改变。②方法用葡聚糖包裹活性炭饱和吸附法（ＤＣＣ法）检测２１例肝细胞癌（ＨＣＣ）癌组织和癌旁组织中ＡＲ，并与７例男性肝硬变病人肝组织中的ＡＲ进行了比较。③结果癌组织中ＡＲ的含量显著高于癌旁组织（ｔ＝２．７９３，Ｐ＜０．０１）及硬变肝组织（ｔ＝２．３２３，Ｐ＜０．０５）。④结论ＡＲ的增加与肝细胞的恶变有关，从而为ＨＣＣ的内分泌治疗提供分子生物学依据。
Objective To study the changes of androgen receptor(AR) in hepatocellular carcinoma(HCC) and the surrounding noncancerous liver tissue. Method The amount of AR in HCC and the surrounding noncancerous liver tissue of 21 patients was determined with dextran-coated charcoal methods and compared with that of seven male patients with cirrhosis. Result The amount of AR in HCC was significantly higher than in the surrounding noncancerous liver tissue( t=2.323,P<0.05) and in cirrhosis patients( t=2.793,P <0.01). Conclusion The result suggested that the increment of AR expression was correlated with the malignant change of hepatocyte. This correlation provided molecular biologic basis for endocrine treatment.
出处
《青岛医学院学报》
1996年第2期137-138,共2页
Acta Academiae Medicinae Qingdao Universitatis
关键词
肝肿瘤
肝硬变
雄激素
受体
测定
liver neoplasms
liver cirrhosis
receptor, androgen
