摘要
以细胞培养技术对牛膝多糖（Ａｃｈｙｒａｎｔｈｅｓｂｉｄｅｎｔａｔａｐｏｌｙｓａｃｃｈａｒｉｄｅ，Ａｂｐｓ）硫酸酯抗Ⅰ型单纯疱疹病毒药效的实验进行研究。受试药物Ａｂｐｓ硫酸酯（Ａ－５、Ａ－６、Ｂ－３、Ｂ－４、Ｂ－５、Ｃ－６、Ｃ－７、Ｃ－８）和对照药物环胞苷（ＣＣ）、亚膦酰乙酸（ＰＡＡ）按照综合药效指数评价时，排列顺序为Ａ－６（２．１７）＞ＣＣ（２．１１）＞ＰＡＡ（２．０４）＞Ｂ－３（２．０２）＞Ｂ－５（１．９０）＞Ａ－５（１．６０）＞Ｃ－８（１．３８）＞Ｃ－７（１．３２）＞Ｂ－４（０．８４）＞Ｃ－６（０．８０）。由此可见，８种受试的化学合成药牛膝多糖硫酸酯中Ａ－６为抗Ⅰ型单纯疱疹病毒效果较佳新药，本品优于环胞苷和亚膦酰乙酸。
he application of tissue culture technique using human embryo muscle skin monolayer cells was made for type Ⅰ herpes simplex virus (HSV Ⅰ) inhibiting.Achyranthes bidentata polysaccharide sulfate (Abpss) were used.The efficacy index were listed in the following order:Abpss A 6 ( 2.17 )>Cyclocytidine (CC) ( 2.11 )>Phosphonoacetic (PAA) ( 2.04 )>Abpss B 3 ( 2.02 )>Abpss B 5 ( 1.90 )>Abpss A 5 ( 1.60 )>Abpss C 8 ( 1.38 )>Abpss C 7 ( 1.32 )>Abpss B 4 ( 0.84 )>Abpss C 6 ( 0.80 ).The Abpss A 6 exceeded such control drugs (synthetic compounds) as CC and PAA.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1996年第11期483-486,共4页
Chinese Journal of Hospital Pharmacy
基金
国家自然科学基金资助项目
关键词
牛膝多糖硫酸酯
细胞培养
单纯疱疹病毒
Achyranthes bidentata polysaccharide sulfate (Abpss),tissue culture technique,Anti type Ⅰ herpes simplex virus (HSV Ⅰ)
