摘要
目的:应用Meta分析方法进一步了解碟脉灵注射液治疗急性脑梗死的临床疗效和安全性。方法:①于2006-03检索中国期刊网全文数据库1994-01/2006-12关于碟脉灵注射液(苦碟子制剂)治疗脑梗死的文章27篇,主题词包括碟脉灵注射液和急性脑梗死。文献纳入标准:论文内容包含有碟脉灵注射液治疗急性脑梗死的对照研究;治疗效果以改良的爱丁堡一斯堪的那维亚量表的量化性质反映出来。②应用Meta分析方法对检索出的符合要求的11项研究进行同质性检验,计数资料采用四格表数据的Meta分析方法(Peto法)计算比值比(OR)和95%可信区间(CI)。计量资料计算合并检验统计量(Z)及合并效应指数(d平均)。结果:最初纳入文献27篇,最终纳入Meta分析的文献11篇。①同质性检验结果:χ2=6.66,自由度为10,P>0.05。②两组疗效合并效应量的检验结果:碟脉灵治疗组的总有效率明显高于对照组[90.0%,80.2%,χ2=29.32,P<0.01(OR=2.51,95%CI:1.78～3.50)]。③临床神经功能缺损评分结果显著性检验:碟脉灵治疗组的Z1=31.25,P<0.01;对照组的Z2=18.16,P<0.01。表明两组患者经治疗后神经功能缺损均有显著改善,且碟脉灵治疗组的疗效优于对照组(Z1>Z2);效应大小评估:碟脉灵治疗组的d平均=1.84(d平均=0.8为大效应),对照组的d平均=1.32,提示两组治疗的效应均很大,且碟脉灵治疗组的效应大于对照组。④碟脉灵治疗组均未见明显不良反应出现。结论:碟脉灵注射液治疗急性脑梗死的疗效显著优于目前常用药物,且无明显不良反应。
AIM：To further investigate the clinical effectiveness and reliability of Diemaining injection in the treatment of acute cerebral infarction （ACI） by using Meta-analysis.
METHODS： ①Using the key terms of ＂Diemaining injection, acute cerebral infarction＂, we searched the Chinese Journals Full-text Database in March 2,006 for the articles about the treatment of ACI by Diemaining injection published from January 1994 to December 2006. The inclusive criteria： The controlled trials were about Diemaining injection for treating ACI, and the curative effects were in accordance witti modified Edinburgh Scandinavia stroke scale （mESS）. Then 27 articles were retrieved.②Metaanalysis was used to conduct homogeneity test in 11 studies meeting the criteria. For the enumeration data, the fourfold Meta analysis （Peto） was used to calculate the odds ratio （OR） and 95% confidence interval （CI）. While as for the measurement data, combined test statistical （Z） and relative risk （RR） index （dmean） were counted.
RESULTS：A total of 27 articles were included, and 11 of them were enrolled in Meta analysis.①）Homogeneity test： x^2=6.66, free degree 10, P 〉 0.05.②RR of curative effects： The total effective rate in treatment group was significantly higher than in control group [90.0%, 80.2%, x^2=29.32, P 〈 0.01 （OR=2.51, 95%CI： 1.78-3.50）].③The hypothesis testing of Chinese stroke scales （CSS） scores in ACI patients： Treatment group： Z1=31.25, P 〈 0.01; Control group： Z2=18.16, P 〈 0.01, which indicated that the neurological impairments of patients in two groups were both improved after Diemaining injection, and the curative effect was better in treatment group than in control group （Z1 〉 Z2）; Effect： Treatment group： dmean =1.84 （dmean=0.08 as great effect）; Control group： dmean=1.32, which indicated that both of the effects in two groups were great, and the effect was greater in treatment group than in control group. ④There was no obvious adverse reaction found in the treatment group.
CONCLUSION：The therapeutic effects of Diemaining injection for ACI is significantly superior to other medications used at present, and it has few adverse reactions.
出处
《中国临床康复》
CAS
CSCD
北大核心
2006年第27期100-101,共2页
Chinese Journal of Clinical Rehabilitation
