摘要
目的应用Meta分析方法进一步了解杏丁注射液治疗急性脑梗死的临床疗效和安全性。方法实验于2005-11在东莞市人民医院进行,应用计算机检索中国期刊网全文数据库(CNKI,1994/2005),主题词包括杏丁注射液和急性脑梗死。文献纳入标准是:论文内容包含有杏丁注射液治疗急性脑梗死的对照研究;治疗效果以量表的量化性质反映出来,且为计数资料。应用Meta分析方法对检索出的符合要求的15项研究进行同质性检验和合并效应量的检验。结果①同质性检验:χ2=3.95,自由度为14,P>0.05。②合并效应量的检验:治疗组的总有效率为91.63%,显著优于对照组的76.87%,χ2=71.72,P<0.001(OR合并:3.18,95%CI:2.44￣4.16)。③15项研究中,治疗组均未见明显不良反应出现。结论杏丁注射液治疗ACI的疗效显著优于目前常用药物,且无明显不良反应。
Objective To further investigate the effectiveness and safety of Xingding injection in treatment of acute cerebral infarcton （ACI） by using Meta-analysis. Methods Experiment was conducted in Department of Neurology, Donggnan peoples＂ Hospital in November 2005. Using the key terms ＂Xingding injection, ACI＂, we searched the Chinese journals full-text database from 1994 to 2005. The inclusive criteria： randomized controlled trials were about Xingding injection for treating ACI; the results were measurement data. Meta-analysis was used to detect homogeneity test and combined test in 15 studies meeting the criteria were. Results ① Homogeneity test shows that the cited 15 studies are homogeneous with P〉0.05. ②combined test shows that the total effectiveness rate in treatment group were significantly better than control group with X^2=71.72,P〈0.001 （OR=3.18,95%CI：2.44-4.16）. ③In 15 studies, the treatment group had few side effects. Conclusion The therapeutic effects of Xingding injection for ACI is significantly superior to other medications used at present, and it has few side effects.
出处
《中国现代医药杂志》
2006年第3期32-34,共3页
Modern Medicine Journal of China
