摘要
为了探讨肠上皮化生在胃癌发生方面的意义，作者采用粘液组织化学染色、核仁组成体区相关嗜银蛋白（ＡｇＮＯＲ）染色等方法研究了９３例胃癌癌旁肠上皮化生的特点。结果显示癌旁肠上皮化生的检出率为８０．６４％，大肠型肠上皮化生检出率５８．０６％，不完全性大肠型肠上皮化生检出率１７．２０％；７例早期胃癌中５例伴有肠上皮化生；肠上皮化生及其各种亚型在肠型胃癌和弥漫型胃癌之间的差别无显著意义（Ｐ＞０．０５）；肠上皮化生ＡｇＮＯＲ数目（２．１５±０．４９）明显多于正常幽门腺（Ｐ＜０．０１），ＡｇＮＯＲ直径（１．５８±０．４８μｍ）明显小于正常幽门腺（Ｐ＜０．０５），与胃癌细胞的差别均无显著意义。讨论认为伴有明显异型增生的肠上皮化生属于胃癌的癌前病变。
In order to investigate the intestinal metaplasia(IM) and the pathogenesis of the gastric carcinoma,the authors studied the IM of pericancer in 93 cases of gastric carcinoma by means of mucous staining and the nucleolar organizer region-associated argentrophil proteins(AgNORs) staining.The results demonstrated the IM of 80.64%(75/93),colon-type IM of 58.06% and incomplete colon-type IM of 17.20% in 93 cases of gastric adenocarcinoma.IM was found in 5 out of 7 cases of early gastric cancer.No significant relationship was found between IM and its subtype and intestinal-type and diffuse gastric carcinoma( P >0.05).The numbers of AfNORs in IM(2.15±0.49) was significantly higher than that in normal pyloric glands( P <0.01).The diameters of AgNORs in IM(1.58±0.48u)was significantly less than that in pyloric glands( P <0.05).No significant difference of AgNORs was found between the IM and gastric carcinoma.It is suggested that the IM with obvious dysplasia belong to the precancerous lesions of gastric carcinoma.
出处
《宁夏医学杂志》
CAS
1996年第4期207-209,共3页
Ningxia Medical Journal
关键词
胃肿瘤
病理学
肠上皮化生
Stomach neoplasms
lntestines
histological change
