摘要
目的:研究番茄红素对二乙基亚硝胺(DEN)所致氧化损伤的拮抗作用。方法:健康雄性Wister大鼠,随机分为4组。对照组正常饮水,损伤组、低剂量组、高剂量组饮用0.01%DEN水溶液,高低剂量组按20 mg/kg及10mg/kg灌胃溶有番茄红素的色拉油,30 d后,测定血清、肝匀浆抗氧化酶的含量。结果:损伤组与对照组比较SOD、GSH-Px、T-AOC明显下降,MDA显著增高;高剂量组大鼠血清SOD、T-AOC活力显著升高;高、低剂量组血清GSH-Px活力显著高于损伤组,MDA含量显著低于损伤组。高、低剂量组肝匀浆SOD、T-AOC活力均显著高于损伤组;高剂量组肝匀浆GSH-Px显著高于损伤组,MDA显著低于损伤组。结论:DEN可致大鼠体内抗氧化酶活性降低,番茄红素能够提高大鼠抗体抗氧化能力,对DEN所致的脂质过氧化损伤具有一定的保护作用。
Objective： To study the protection of lycopene on the lipid peroxldation induced by DEN. Methods： Wister rots were divide into 4 groups randomly with 8 mrs in each group： control group （give salad oil）, model group （drink DEN and give salad oil）, low dose and high dose group （drink DEN and give salad oll with lycopene by 10 mg/kg and 20 mg/kg respectively）. After 30 days, the activity of SOD, GSH-Px, T-AOC and content of MDA were measured. Resultsi The activity of SOD, GSH-Px, T - AOC increased remarkable in high does group, the activity of GSH-Px at high does and low does group increased remarkably, the level of MDA decreased remarkably in high does and low dose group. In liver the activity of SOD, T - AOC increased remarkably in high does and low does group, the activity of GSH-Px increased remarkably in high does group, the level of MDA decreased remarkably in high does group. Conclusion： DEN can result in the oxidative damage in rots. Lycopene can increase the activity of antioxidative enzymes, as well as decrease the lipid peroxidative damage.
出处
《现代预防医学》
CAS
北大核心
2006年第7期1093-1093,1104,共2页
Modern Preventive Medicine
