摘要
目的评价NEF方案用于可手术乳腺癌新辅助化疗的近期疗效及其不良反应。方法2000至2004年应用NEF方案治疗Ⅱb-Ⅲ期可手术乳腺癌患者52例。NEF方案：长春瑞滨（NVB）30mg／m^2，d1，5；EPI 50mg／m^2，d1；5-Fu 500mg／m^2，d1～5。28d为1个周期，所有患者完成2个周期新辅助化疗后评价疗效，化疗结束后2～3周手术。结果34例（65．4％）降低了临床分期；其中完全缓解（CR）3例（5．8％），病理完全缓解（pCR）2例（3．8％），部分缓解（PR）35例（67．3％），病变稳定（SD）14例（26．9％），全组无疾病进展（PD）者，总有效率（CR＋PR）为73．1％。Ⅱb期、Ⅲa期、Ⅲb期有效率分别为83．3％（15／18）、69．6％（16／23）和63．6％（7／11），Ⅱb期有效率高于Ⅲa期和Ⅲb期。新辅助化疗2个周期后有42．0％（21／50）未触及肿大淋巴结；46．0％（23／50）肿大淋巴结明显缩小，腋窝淋巴结总有效率为88．0％（44／50）。毒副反应为白细胞下降、恶心呕吐、脱发、神经毒性和周围静脉炎等，患者均可耐受。结论NEF方案用于可手术乳腺癌新辅助化疗，对原发灶和腋窝淋巴结均有较高的有效率，而且可以降低临床分期，不良反应可耐受，值得推广。
Objective To evaluate the efficacy and adverse effect of NEF regimen as neoadjuvant chemotherapy in the treatment of operable breast cancer. Methods Fifty-two patients with stage Ⅱ b-Ⅲ breast cancer were treated with NEF regimen for 2 cycles every 28 days. Accroding to the effectiveness standard and toxic grading standard suggested by WHO,efficacy and safety were evaluated after 2 cycles of neoadjuvant chemotherapy. The NEF regimen consisted of vinorelbine （NVB） 30 mg/m^2, d1,5 ;EPI 50 mg/ m^2 ,d1 ;5-Fu 500 mg/m^2 ,d1-5. Results The TNM stage was lowered in 34（65.4% ） patients. The overall response rate （RR） of the primary tumor was 73.1% （38/52） ,induding complete response （CR） in 3 cases, partial response （PR） in 35 cases and pathologic complete response （pCR） in 2 cases. There was no disease progressive（PD）. The overall response rate of stage Ⅱ b, Ⅲa and Ⅲ b were respectively 83.3% （15/18） ,69.6 % （16/23） and 63.6% （7/11 ）. Clinically palpable axillary lymph nodes which had been found in 50 patients before treatment,42.0% （21/50） became inpalpable. The major toxicity included leukopenia, gastroenteric reactions, alopecia, neurotoxicity and peripheral phlebitis, which were all mild. Condusions Neoadjuvant chemotherapy with NEF regimen could diminish the primary tumor and axillary lymph nodes of operable breast cancer. NEF regimen is effective and has acceptable tolerance for preoperative treatment of operable breast cancer.
出处
《中国肿瘤临床与康复》
2006年第3期247-249,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
乳腺肿瘤/外科学
新辅助化疗
Breast neoplasms/surgery
Neoadjuvant chemotherapy
