摘要
目的了解诺维本加顺铂(NP)新辅助化疗方案在局部晚期乳腺癌综合治疗中的作用.方法23例Ⅱb至Ⅲb期的乳腺癌患者,术前均经细胞学检查证实.化疗用药为诺维本(NVB)25mg/m2 d1,8+顺铂(DDP)25mg/m2 d1～3,每3周为1周期,术前用药3周期后评价疗效.结果本组总体化疗有效率为86.9%,肿瘤原发灶完全缓解(CR)1例,部分缓解(PR)19例,无变化(SD)3例;腋淋巴结临床CR 4例,PR 15例,SD 4例.78.3%患者可以在3个周期的新辅助治疗后病情缓解,行手术根治治疗.毒副反应主要为骨髓抑制和消化道反应.结论NP方案作为局部晚期乳腺癌新辅助化疗方案有效率高,毒副反应可以耐受,值得进一步研究.
Objective To evaluate the effect of combined navelbine （NVB） and cisplatin （DDP） （NP） as a neoadjuvant chemotherapy in the treatment of locally advanced breast cancer （LABC）. Methods 23 cases of LABC （ Ⅱb -Ⅲ b） were treated with NP chemotherapy before operation. The neoadjuvant chemotherapy regimen, containing NVB （ 25 mg/m^2 on dl and d8） and DDP （25 mg/m^2 on dsl - 3） were administered every 3 weeks for 3 cycles before local surgery. Clinical responses in the breast and lymph nodes were assessed after 3 cycles of neoadjuvant chemotherapy. Results In the primary tumor, the clinical objective response rate was 86.9% （1/23 CR and 19/23 PR） ; in the regional lymph nodes, the rate was 82.6% （4/23 CR and 15/23 PR）. Eighteen of the 23 （78.3%） patients became operable after 3 cycles of neoadjuvant chemotherapy. The common toxicities encountered were leukopenia and digestive tract reactions. Conclusion The combination of NVB and DDP （NP） is an effective neoadjuvant chemotherapy for the LABC, with tolerable toxicities, and deserves further observation.
出处
《徐州医学院学报》
CAS
2005年第5期411-414,共4页
Acta Academiae Medicinae Xuzhou
关键词
化学治疗
晚期乳腺癌
诺维本
顺铂
neoadjuvant chemotherapy
locally advanced breast cancer
navelbine
cisplatin
