摘要
目的：探讨不同致“阳虚”药物对雄大鼠骨代谢的影响。方法：实验用３月龄ＳＤ大鼠３２只，随机分为对照组（Ａ１）组１、对照组（Ａ２）组２、激素（Ｂ）组和羟基脲（Ｃ组），Ａ１和Ａ２组灌喂生理盐水１ｍｌ／ｋｇ，Ｂ组灌喂泼尼松４．５ｍｇ／ｋｇ，Ｃ组灌喂羟基脲０．２５ｇ／ｋｇ，每周３次，３个月后用图象分析仪对四组大鼠胫骨中段的骨片进行动态及静态测算和分析。结果：Ｂ组和Ｃ组分别与Ａ１组和Ｂ１组比较，都出现骨吸收大于骨形成，导致骨量丢失，从而出现皮质骨变薄，骨髓腔增大。结论：致“阳虚”药物泼尼松和羟基脲均可引起大鼠骨质疏松，但二者所造成骨量丢失的机理不尽相同。
This aricle is trying to explore the effect of the different drugs to induce Yang-insufficiency on bone metabolism in male rats.Thirty-two male Sprague-Dawley rats at 3 months of age were used in experimental study.They were randomly assigned to control (A1)and (A2) group,hormone (B) group and hydroxyurea (C) group:the group A1 and A2 were respectively given normal saline 1ml/kg,ig,the group B given prednisone acetate 4.5mg/kg,ig,twice a week,and the group C given hydroxyurea 0.25g/kg,ig,3 times a week.The dynamic and static histomorphometric parameters of sections of tibial shaft in four groups were measured and calculated with Quantitative Bone Histomorphometry after 3 months.The results were as follows:The cortical bone declined and the marrow area increased in the B and C group as compared separately with the gruop A1 and A2 due to bone resorption exceeding formation.The date indicates that osteoporotic model can be estabalished by prednisone and hydroxyurea,and that a marked bone loss can be induced in the insufficiency of the kidney-Yang in rats.
出处
《中国中医骨伤科》
1996年第5期1-4,共4页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
关键词
醋酸泼尼松
羟基脲
骨质疏松
骨代谢
药理学
prednisone acetate
hydroxyurea
osteoporosis
cortical bone,bone histomorphometry.
