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比索洛尔治疗扩张型心肌病充血性心力衰竭的疗效观察 被引量:1

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摘要 目的观察比索洛尔治疗扩张型心肌病充血性心力衰竭的临床疗效。方法48例患者均在常规强心、利尿、血管紧张素转换酶抑制剂(ACEI)或血管紧张素Ⅱ受体拮抗剂(ARB)治疗基础上,加用比索洛尔,初始剂量为1.25mg/d,每2周剂量上调1次,剂量递增幅度为1.25~2.50mg/次,直到最大耐受剂量或推荐的靶剂量(10mg/d),用药16周。治疗前后检查超声心动图各项指标及测量血压、心率变化以作对照。结果治疗16周后心功能改善Ⅱ级24例,改善Ⅰ级17例,总有效率为85.4%,超声心动图示:左室收缩内径(LVESD)较用药前缩小(P<0.01),左室射血分数(LVEF)、左室短轴缩短率(FS)、心排血指数(CI)、心输出量(CD)及每搏量(SV)较治疗前显着增高(P<0.001和P<0.01),治疗后心率减慢、血压下降(P<0.01),差异有显着性意义,未见毒副反应发生。结论扩张型心肌病合并充血性心力衰竭患者在常规治疗基础上联用比索洛尔可使临床症状及心功能改善,提高生活质量,安全可靠。
作者 胡林骅
机构地区 乐平市人民医院
出处 《基层医学论坛(B版)》 2006年第2期101-102,共2页 Public Medical Forum Magazine
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