摘要
目的探讨妊娠高血压综合征(简称妊高征)患者剖宫产前应用地塞米松、维生素E及维生素C对产妇及胎儿超氧化物歧化酶(SOD)及脂质过氧化物(LPO)的影响。方法选择硬膜外麻醉下行择期剖宫产术妊高征产妇51例,随机分成观察组(A组,26例)和对照组(B组,25例)。术前应用地塞米松20mg、维生素E200mg及维生素C1000mg。测定用药前、用药后1h及胎儿娩出时产妇及脐带血SOD及LPO浓度。结果A组产妇在胎儿娩出时LPO较B组及同组用药前降低(P<0·01),脐带血LPO低于B组(P<0·01)。结论妊高征产妇术前联合应用地塞米松、维生素E及维生素C有到明显的抗氧化作用,可降低产妇及胎儿的LPO浓度。
Objective To investigate the effect of preoperative administration of dexamethasone,Vit E and Vit C on superoxide dismutase （SOD）and lipid peroxide （LPO）of fetus and parturient with pregnancy hypertension undergoing Cesarean section. Methods Fifty-one parturients with hypertension of pregnancy undergoing Cesarean section under epidural anesthesia were divided randomly into group A（n=26） and group B（control group,n=25 ）. All parturients in group A were given dexamethasone 20 mg,Vit E 200 mg and Vit C 1 000 mg before operation . Plasma SOD and LPO concentration in parturients and cord blood of fetus were measured before antioxidant, 1 h after drug administration and the time after newborn delivery. Results Plasma LPO concentration in parturients of group A was obvioushly decreased after newborn delivery compared with that of group B. Meanwhile, cord blood LPO concentration was significantly decreased. Conclusion Preoperative administration of antioxidant in the parturient with hypertension of pregnancy could decrease plasma LPO concention in parturient and fetus.
出处
《临床麻醉学杂志》
CAS
CSCD
2006年第6期427-428,共2页
Journal of Clinical Anesthesiology
