摘要
目的 :探讨妊高征产妇在剖宫产术前应用抗氧化药物地塞米松、维生素 E及维生素 C对母儿超氧化物歧化酶 (SOD)及脂质过氧化物 (L PO)的影响。方法 :选拟行择期剖宫产术的妊高征孕妇 2 4例 ,平均分为 A(对照组 )、B(实验组 )两组。 A组术前不用药 ,B组于术前 3d及手术当日每日静脉输入地塞米松 2 0 mg+维生素 C1g,口服维生素 E2 0 0 m g。测定用药前、麻醉前及术中取胎儿时产妇血和脐动、静脉血 SOD及 L PO浓度。结果 :用药后产妇和脐带血 L PO值均显著降低 ;产妇 SOD值显著升高 ,脐带血 SOD与 A组相比差异不显著。结论 :妊高征产妇在剖宫产术前联合应用地塞米松、维生素 E及维生素 C使母儿 L PO明显降低 ,产妇 SOD明显升高 ,起到了较强的抗氧化作用。
Objective: Our purpose was to investigate the effects of dexamethasone, vitamin C, and vitamin E administered before cesarean section to parturient suffering from pregnancy hypertension on superoxide dismutase (SOD) and lipid peroxides (LPO) in maternal and fetal blood. Methods: Twenty four women with pregnancy hypertension undergoing elective cesarean section were equally divided into two groups. Patients in group A received no drug administration, and patients in group B received dexameshason (20 mg), vitamin C (1 g), and vitamin E (200 mg) one day, 3 days before operation and on the operation day. The maternal blood samples for LPO and SOD measurment were taken before administraiton and anesthesia, as well as at the time following immediate delivery in group B and at the same interval in group A, respectively. Umbilical cord blood samples were also taken from the two groups for those measurments. Results: In group B, the concentration of LPO in maternal and umbilical cord blood and the concentration of SOD in maternal blood decreased significantly after the administration. There was no significant difference in the concentration of SOD in umbilical cord blood between the two groups. Conclusion: The combination administration of dexamethasone, vitamin C, and vitamin E used before cesarean sectionin can decrease the production of LPO in parturient and fetus, and increase the production of SOD in parturient, which might have protective effects on peroxidative injuries in parturient with pregnancy hypertension during cesarean sectionin.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2000年第5期387-388,共2页
Journal of China Medical University
