摘要
目的:探讨半夏药材中总生物碱部位的抗炎作用。方法:通过二甲苯致小鼠耳廓肿胀实验、腹腔注射醋酸(HAC)所致小鼠腹腔毛细血管通透性增高的实验以及大鼠棉球肉芽肿实验,观察总生物碱部位的抗炎作用;制作小鼠气囊滑膜炎模型,测定炎症渗出物中前列腺素E2(PGE2)含量。结果:半夏生物碱对二甲苯致小鼠耳廓肿胀、醋酸致小鼠毛细血管通透性的增加以及大鼠棉球肉芽肿的形成均有明显的抑制作用,生物碱组渗出液中前列腺素E2含量明显低于模型组。结论:半夏总生物碱部位对多种炎症模型均有明显的对抗作用,为半夏抗炎作用的主要有效部位之一。且此作用部分是与炎症因子PGE2的产生和释放受抑制有关。
Objective： To investigate the anti-inflammation effect of the tatal alkaloid in Pinellia temata （Thunb.） Breit. Methods： Various inflammatory models, including the swelling of ear induced by xylene in mice, the permeability increase of blood capillary by HAc in mice, and the cotton-pellet granuloma of the rat were used to explore the anti-inflammation of the tatal alkaloid. Air sac models of synovitis in mice were set up and the content of prostaglandinE2 （PGE2） was measured in inflammatory exceduate. Results： The tatal alkaloid has significant inhibitory action on auris swell induced, by xylene in mice and penetration of capillary vessel in mice. The general alkaloid also decreased the proliferation of granuloma caused by implantation cotton pellet in rats significantly. The content of PGE2 in the experimental groups were obviously lower than those in the control groups. Conclusion： The tatal alkaloid has significant anti-inflammation, which is relevant to the inhibition of the production and release of the inflammatory factor PGE2.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第3期87-89,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
半夏
总生物碱
抗炎作用
Pinellia ternata （Thunb.） Breit.
tatal alkaloid
anti-inflammatory effect
