摘要
目的:比较苍耳子、辛夷配伍前后4种水煎液灌胃给予动物所产生的急性毒性反应与抗炎作用。方法:急性毒性实验,采用小鼠灌胃给药测定其最大耐受量(MTD);抗炎实验采用二甲苯致小鼠耳肿胀实验及大鼠棉球肉芽肿实验。结果:苍耳子单煎液小鼠灌胃给药的MTD大于60 g生药/kg、辛夷单煎液小鼠灌胃给药的MTD大于120 g生药/kg、苍耳子与辛夷配伍后水煎液小鼠灌胃的MTD大于180 g生药/kg;与对照组相比各给药组都具有一定的抗炎作用,作用强弱顺序为:吲哚美辛组>样品3组>样品2组>样品4组>样品1组。结论:本实验结果表明,苍耳子、辛夷配伍后合煎液的抗炎作用较苍耳子单煎液有所增强,且急性毒性小于苍耳子单煎液。
Objective： To compare the acute toxicity and anti-inflammation effects in vivo of 4 decoctions before and after the combination of Fruit of Siberian Cacklebur with Magnolia Flower. Methods： The acute toxicity was tested using the maximum tolerated dose method in mice. The anti-inflammation action was studied on rat models of adjuvant arthritis induced by FCA and mouse models of xylene induced ear edema. Results： The maximum tolerated dose of Fruit of Siberian Cocklebur decoction in mice was more than 60g （crude drug） /kg; the maximum tolerated dose of Magnolia Flower decoction was more than 120 g （crude drug） /kg. the maximum tolerated dose of Fruit of Siberian Cocklebur compatibility with Magnolia Flower was more than 180 g （crude drug） /kg. Compared with control group, each model group had anti-inflammation effects of which strength were as below： indometacin group 〉 model group three 〉 model group two 〉 model group four 〉 model group one. Conclusion： This study indicated that mingled decoction of Fruit of Siberian Cocklebur and Magnolia Flower had a better anti-inflammation effect as well as less acute toxicity compared with decoction of Fruit of Siberian Cocklebur.
出处
《成都中医药大学学报》
2012年第3期26-28,38,共4页
Journal of Chengdu University of Traditional Chinese Medicine
基金
成都中医药大学科技发展基金(编号:ZRYB201003)
关键词
苍耳子
辛夷
配伍
急性毒性
抗炎
Fruit of Siberian Cocklebur
magnolia flower
compatibility
acute toxicity
anti-inflammatory
