摘要
目的探讨腔隙性脑梗死认知缺损(Lacunar Infarction Cognitive Impairment,LICI)的证候学特点及证类分布特征,为确定本病防治方案提供依据。方法将80例腔隙性脑梗死(LI)患者作为一个研究队列进行量表评分,分为LICI组44例,LI组36例,制定并采用统一的中医证候学观察表,对两组患者证候因素进行观察。结果①LICI组65.90%病人是多病灶、多部位损害,病灶部位以优势半球分布为多。②LICI组63.63%病人记不清楚认知缺损起病时间,70.45%病人病情是不断加重。③LICI组有不同程度的认知功能下降,部分病人伴有抑郁症状出现。④LICI主要的证候要素和证候类型为风、火、痰、瘀、肝肾阴虚、脾肾阳虚。结论LICI起病隐匿,呈渐进加重,以多灶多位损害为主;肾虚是LICI发生的根本因素,风火痰瘀,兼夹蕴化是发展加重的关键。
Objective To investigate symptom and syndrome apparent in Lacunar Infarction （LI） patients with cognitive impairment. The analysis of this study will help to find the risk factors of cognitive impairment in LI patient so as to provide a fundamental preventing and treatment strategy through the use of TCM. Method Epidemiological survey was adopted in the study, including inquiry to 80 patients divided into 2 groups ： 44 patients in the LICI group and 36 patients in the LI group, according to unified standards, filling out questionnaire for symptoms and signs, investigating frequencies of different symptoms and TCM syndromes, statistical data processing by using SPSS 12.0 software, investigating occurrence rate of different TCM syndromes, and carry-out of etiological analysis. Results ①65.90% of the patients of the LICI group suffered from multiple cerebral infarctions, in group LICI, lacunar infarctions often happened and damaged in the area of dominant hemisphere. ②3.63 % of the patients of the LICI group could not remember when the first onset of cognitive impairment occurred, and 70.45% of the course of cognitive impairment was aggravating constantly. ③The study showed that the LICI group had cognitive function decline in different degrees, while some patients in the LICI group appear with onset of LI cognitive impairment usually is insidious, and memory loss of LI cognitive impairment often deteriorated slowly. According to TCM theory, LICI occurs due to kidney deficiency. In addition, other important factors included wind, fire, phlegm, and blood stagnation. The origin of LI cognitive impairment might be due to kidney deficiency. After LI happened, the key reason for occurrence of cognitive impairment was kidney deficiency, and the main factors that caused the course of cognitive impairment deterioration could be from the toxins of combination of fire, blood stagnation, wind, and phlegm.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2006年第5期350-354,共5页
Journal of Beijing University of Traditional Chinese Medicine
基金
211工程重点学科建设项目
2005年教育部科学技术重点项目
关键词
腔隙性脑梗死认知缺损
证候学
观察分析
Lacunar Infarction Cognitive Impairment （LICI）
TCM symptomatology
TCM etiology
