摘要
目的探讨血清一氧化氮、抗胰岛素自身抗体(IAA)在原发性高血压患者中的变化及意义。方法对45例原发性高血压患者及40例健康对照者进行血清一氧化氮含量及IAA测定,采用硝酸还原酶法检测一氧化氮含量,采用ELISA法检测IAA。结果高血压患者血清一氧化氮水平明显减低,与对照组比较差异有显著性[(71.68±11.72)μmol/L与(81.25±10.56)μmol/L,P<0.01],高血压患者IAA阳性率为33%,较对照组(10%)显著增高(P<0.05)。结论血清一氧化氮水平含量的减低、IAA的产生可能与高血压的发生、发展有关。及早采取干预可能是改善血管内皮功能、减轻胰岛素抵抗状态、促使原发性高血压患者血压恢复的有益措施。
Objective To investigate the changes of serum nitric oxide （NO） and insulin autoantibody （IAA） in patients with essential hypertension （ EH）. Methods The levels of serum NO were analyzed by the method of nitrate rcductase and IAA levels were determined by ELISA in 45 patients with EH and 40 healthy subjects. Results The levels of NO in patients with EH were decreased significantly, with significant difference comμpared with control group [ 171.68 ± 11.72） μmol/L vs. 181.25 ± 10.56） mol/L,P 〈 0.01 ] ,and IAA positive rate was higher than that of control group [ 33 % vs 10% ,P 〈 0.05 ]. Conclusion The decreased concentration of serum NO and production of IAA might be correlated with the development of hypertension. Early intervention may improve endothelial function of blood vessel, reduce insulin resistance and promote blood pressure recovery of essential hypertension.
出处
《中国综合临床》
北大核心
2006年第7期585-586,共2页
Clinical Medicine of China
