摘要
目的:探讨转化生长因子α(transfor-ming growth factor alpha,TGF-α)在胰腺癌组织中的表达与临床病理因素的关系。方法:用免疫组织化学方法(SP法)检测31例胰腺癌及对应癌旁组织中TGF-α的表达水平,并对实验结果进行统计学分析。结果:31例胰腺癌中TGF-α的阳性表达18例(58·06%),明显高于对应癌旁组织;同时发现TGF-α在癌旁神经组织中高表达。结论:与对应癌旁组织相比,胰腺癌组织中的TGF-α表达水平明显上升,P<0·011,TGF-α在癌旁神经组织中的高表达可能是胰腺癌神经浸润转移的机制之一。
OBJECTIVE：To study the TGF-α expression in pancreatic carcinoma and its relationship with cliniclopathological parameters. METHODS： Expression of TGF-α was examined by the immunohistochemical method. RESULTS： The positive rate of TGF-α was 58.06%, being significantly higher than that of the matched normal tissue, while the overexpression of TGF-α in nervous tissue was found. CONCLUSIONS： Compared with the matched normal tissue, the expression of TGF-α in pancreatic carcinoma is higher, P〈 0. 011. The over-expression of TGF-α in nervous tissue may play an important role in nervous infiltration of pancreatic carcinoma.
出处
《中华肿瘤防治杂志》
CAS
2006年第7期512-514,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
胰腺肿瘤/病理学
神经系统/病理学
转化生长因子Α
免疫组织化学
pancreatic neoplasms/pathology, nervous system/pathology
transforming growth factoralpha
immunohistochemistry
