摘要
Non-steroidal anti-inflammatory drugs （NSAIDs） including cydooxygenase 2 （COX-2） selective inhibitors, are potential agents for the chemoprevention of gastric cancer. Epidemiological and experimental studies have shown that NSAID use is associated with a reduced risk of gastric cancer although many questions remain unanswered such as the optimal dose and duration of treatment. The possible mechanisms for the suppressor effect of NSAIDs on carcinogenesis are the ability to induce apoptosis in epithelial cells and regulation of angiogenesis. Both COX-dependent and COX- independent pathways have a role in the biological activity of NSAIDs. Knowledge of how NSAIDs prevent neoplastic growth will greatly aid the design of better chemopreventive drugs and novel treatments for gastric cancer.
包括 cyclooxygenase 的 Non-steroidal 反煽动性的药(NSAID ) 2 (COX-2 ) 选择禁止者，是为胃的癌症的 chemoprevention 的潜在的代理人。尽管许多问题仍然保持未答复例如治疗的最佳的剂量和持续时间，流行病学、试验性的研究证明了 NSAID 使用与胃的癌症的减少的风险被联系。为致癌作用上的 NSAID 的 suppress 或效果的可能的机制是在血管生成的上皮细胞和规定导致 apoptosis 的能力。艇长依赖者和艇长无关的小径在 NSAID 的生物活动有一个角色。NSAID 怎么阻止肿瘤的生长的知识将极大地为胃的癌症帮助更好的 chemopreventive 药和新奇治疗的设计。
