摘要
目的制备奥沙普秦凝胶剂并对凝胶剂稳定性进行研究。方法采用Franz扩散池,以大鼠离体皮肤为屏障,进行体外渗透性实验。利用正交设计考察药物含量、月桂氮(艹卓)酮浓度以及丙二醇用量对奥沙普秦凝胶剂经皮渗透性的影响。通过稳定性实验考察奥沙普秦凝胶的稳定性。结果凝胶剂处方的最佳组合为：3%月桂氮(艹卓)酮+10%丙二醇+2%奥沙普秦,其体外经皮渗透近似零级过程,稳定性实验的含量测定结果、凝胶剂外观及涂展性均无明显变化。结论奥沙普秦凝胶剂稳定性良好。
OBJECTIVE To study the preparation and the stability of oxaprozin gel. METHODS Permeation test was carded out by using Franz diffusion cell with isolated rat skin in vitro as transdermal barrier. The orthogonal design was used to investigate the effect of the amount of oxaprozin, the concentration of Azone and the dosage of propylene glycol on the transdermal of oxaprozin gel.The stability of oxaprozin gel was measured by stability experiment. RESULTS The optimal formulation of oxaprozin gel was 3 % Azone, 10 % propylene glycol and 2%oxaprozin. The process of percutaneous permeation of oxaprozin gel in vitro was similarly zero order .The results of stability test indicated that there were no marked changes in the content, spread and appearance of gel. CONCLUSION The gel of oxaprozin has good stability.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2006年第10期759-762,共4页
Chinese Pharmaceutical Journal
