摘要
目的评价在本生殖中心开展体外受精-胚胎移植技术(IVF-ET)的安全性和有效性,探讨影响IVF-ET治疗结局的因素。方法总结分析2002年11月至2005年12月在本中心完成的156个IVF-ET周期病历资料。结果完成移植144周期,平均每周期使用果纳芬(29．75±9．01) 支,获卵10．41个,受精率79．12％,卵裂率93．00％,优质胚胎率51．04％,周期临床妊娠率36．81％, 流产率16．98％,异位妊娠率3．77％,多胎率18．87％,中、重度卵巢过度刺激综合征发生率3．85％。年龄≥35岁患者临床妊娠率、获卵率、胚胎冷冻率均低于年龄<35岁患者,周期取消率高于年龄<35 岁患者。有输卵管、卵巢手术史者卵巢低反应发生率增加。结论本中心开展IVF-ET技术是安全和有效的。年龄过大、窦卵泡数过少以及有盆腔手术史等均是影响IVF-ET治疗成功率的因素。
Objective To analyze the various factors in IVF-ET（in vitro fertilization and embryo transfer） which may affect the treatment outcome. Methods A retrospective study was done on 156 IVF-ET cycles from Nov. 2002 to Dec. 2005. Results The embryo transfer of 144 cycles were accomplished in our center, the dosage of Fonal-F was 29. 75q-9. 01 ampules in average. 10. 41 ova were retrieved per cycle in average. The rates of fertilization, cleavage, high quality embryo, clinical pregnancy, abortion, ectopic pregnancy, polycyesis, incidence of medium and sever ovarian hyperstimulation syndrome were 79. 12%, 93.00%, 51.04%, 36. 81%, 16. 98%, 3. 77%, 18. 87% and 3. 85% respectively. The rates of clinical pregnancy, retrieving ova and embryo cryopreservation were lower in the patients with age ≥35 than that with age 〈35 and the canceling rate of the cycle was higher as well. The incidence of low response of ovary to gonadotropin stimulation increased significantly in the patients undergoing a operation on oviduct or ovary. Conclusion The factors affecting IVF-ET outcome include age of patient, the number of antrum follicles and the history undergoing pelvic operation.
出处
《贵州医药》
CAS
2006年第5期402-404,共3页
Guizhou Medical Journal
基金
贵州省科技攻关课题基金资助黔科合计(2001)1214
关键词
体外受精
胚胎移植
治疗结局
治疗周期
Fertilization, in vitro Embryo transfer Treatment outcome
