摘要
目的观察大剂量纳络酮抢救急性海洛英中毒的疗效。方法将急性海洛英中毒患者127例按昏迷程度分为中毒伴浅昏迷组、中毒伴深昏迷组。两组分别随机分为对照组、治疗组和常规治疗组,三组基础治疗相同。治疗组加用大剂量纳络酮,常规治疗组加入常规剂量纳络酮,而对照组不用。结果与对照组和常规治疗组相比,中毒伴浅昏迷患者治疗组苏醒时间缩短,具有显著统计学差异(P<0.01);而中毒伴深昏迷患者治疗组死亡人数及中毒性脑病后遗症明显减少,苏醒时间也缩短,差异具有显著性(P<0.01)。结论应用大剂量纳络酮降低了急性海洛英中毒患者死亡率,明显改善了预后,缩短了昏迷时间。
Objective To evaluate the effects of large dose naloxone in trearment of acute intoxication of Heroin patients. Methods According to the extent of coma, 127 cases were divided into light coma group and deed coma group. Each group was randomly divided into treatment group, control group and general group. The basic treatment in three groups was the same. But the patients in treatment group was given large dose naloxone,the patients in general treatment group was given usual does aaloxone ,and no naloxone was given in control group . The clinical effects were evaluated with death rate ,residual of brain trauma and palinesthesia time. Results The differenes amount three groups in deep coma was significant（ P 〈0.01 ）, while only in palinesthesia time the different amount three groups in light coma was significant（ P 〈 0.01 ）. Conclusion Large dose of naloxone can decrease death rate,improve prognosis and shorten palinesthesia time of acute naloxone of heroin patients .
出处
《临床和实验医学杂志》
2006年第4期326-327,共2页
Journal of Clinical and Experimental Medicine
关键词
纳络酮
急性海洛英中毒
治疗
Naloxone
Acute intoxication of Heroin
Treatment
