摘要
目的 探讨纳洛酮对急性重型颅脑损伤昏迷患者促醒作用以及对预后的影响。方法 将 82例重型颅脑损伤患者 (GCS≤ 8分 )随机分成二组。观察组 42例在常规治疗的基础上加用纳洛酮促醒治疗 ,对照组 40例 ,采用常规治疗。二组于伤后 6个月按GOS预后评分评定预后 ,同时比较二组患者的意识好转率。结果 观察组恢复良好率 (57.1 4 % )与对照组 (32 .50 % )比较差异有统计学意义 (P <0 .0 5)。观察组治疗后 1个月清醒 33例 ,而对照组 2 0例 ,二组清醒率比较差异有统计学意义 (P <0 .0 1 )。二组清醒时间比较 ,观察组为 (1 2 .46± 6 .2 9)d ,对照组为 (1 5 .95± 7.53)d ,差异有统计学意义 ,(P <0 .0 1 )。结论 纳洛酮治疗重型颅脑损伤昏迷患者时不仅能加速清醒 ,还能促进预后 ,提高生活质量。
Objective To investigate the therapeutic effect of naloxone on promoting revival of coma and prognosis after acute severe head injury. Methods 82 cases with acute severe head injury(GCS≤8分)were randomly divided into two groups, treatment group (n=42), which were treated with naloxone except the routine treatment, and control group(n=40), which were treated only with the routine treatment. The clinical prognosis of the patients was evaluated between the two groups after six months since been injuried according to GOS scores and the consciousness improving rate. Results The rate of good recovery was 57.14% in the treatment group, which were significantly higher than 32.50% of the control group(P<0.05). The consciousness of 33 cases after one month in the treatment group had been significantly improved but only 20 cases in control group(P<0.05). The revival time (12.46±6.29 days) in treatment group was significantly higher than that(15.95±7.53 days)in control group (P<0.01). Conclusion Naloxone treatment can promote revival of coma and improve life quality of the patients with acute severe head injury.
出处
《中国煤炭工业医学杂志》
2005年第4期333-334,共2页
Chinese Journal of Coal Industry Medicine
关键词
纳洛酮
颅脑损伤
昏迷
naloxone
acute severe head injury
coma
