摘要
在0.1mol／LHAc－NaAc缓冲溶液（pH4．3）中，阿霉素出现一灵敏的示波极谱导数还原峰，其峰电位为－0．46V（vs．SCE），峰高与阿霉素的浓度在1．0×10－7～2.0×10-6mol／L范围内呈线性关系。相关系数为0．9970，检出限为4．0×10－8mol／L。用于病人尿样的测定，得到满意的结果。用线性扫描与循环伏安法等手段研究体系的极谱与伏安行为。测得参与电极反应的电子数和质子数均为2;扩散系数为1．37×10－6cm2／s。实验表明，该体系属具有吸附性的可逆过程。
A sensitive reduction peak of adriamycin (ADM) is observed by single-sweep os cillopolarography in 0.1 mol/L HAc-NaAc buffer solution (pH 4. 3). The peak potential is -0.46 V(vs. SCE). A linear relationship holds between the peak current and the concentra tion range of 1.0×10-7～2. 0×10-6 mol/L with a detection limit of 4. 0× 10-8 mol/L. The method has been applied to the determination of trace ADM in urine. Both the electron num ber and proton number involved in the electroreduction are 2. The diffusion coefficient D is 1. 37 ×10-6 cm2/s. The electrode reaction is a reversible process with adsorptive characteris 2. tics.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
1996年第7期764-767,共4页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金
关键词
阿霉素
示波极谱法
吸附波
抗肿瘤药
Adriamycin, single-sweep oscillopolarography, adsorptive wave
