摘要
用体外液体单层培养技术研究了小鼠胸腺、脾脏和淋巴结成克隆性基质祖细胞（ＣＦＵ－Ｆ）的辐射敏感性：胸腺ＣＦＵ－Ｆ的Ｄ０值为２．３Ｇｙ，ｎ值为１．５，脾脏为２．８Ｇｙ和１．２，雨淋巴结的则为２．７Ｇｙ及１．４。脾致密型ＣＦＵ－Ｆ亚群的Ｄ０值为２．１Ｇｙ，ｎ＝１．５；而松散型ＣＦＵ－Ｆ亚群的Ｄ０＝４．４Ｇｙ，ｎ＝１．２。这为大剂量辐射损伤混输基质细胞以提高受体免疫造血功能，提供了实验依据。
By using the technics of culture of immuno-stromal progenitors in vitro,we studied their radiosensitivities after irradiation in various doses.The values of D,and n of thymus,spleen and lymph node were 2.3 Gy and 1.5,2.8 Gy and 1.2,2.7 Gy and 1.4 respectively.The radiosensitivity of the CFU-F subgroups which formed dense colonies was significantly higher than that of loose colonies,when cultured in vitro.
出处
《辐射研究与辐射工艺学报》
CSCD
北大核心
1996年第1期59-62,共4页
Journal of Radiation Research and Radiation Processing
基金
国家自然科学基金
关键词
辐射敏感性
细胞存活
免疫器官
放射生物学
Radiosensitivity
Survial cells
Immuno organ
Immuno-stromal progenitors
