摘要
目的:研究凋亡抑制基因Survivin在肺鳞癌组织中的表达及其临床意义。方法:应用免疫组织化学SP法,检测Survivin在35例肺鳞癌组织、10例正常肺组织中的表达。结果:肺癌组Survivin蛋白表达率为71.4%(25/35),显著高于对照组10%(1/10)(P<0.01)。淋巴结转移组Survivin蛋白阳性表达率76.7%(23/30),显著高于无淋巴转移组40.0%(2/5)(P<0.01);随临床分期增加、淋巴结的转移,Survivin蛋白阳性表达率逐渐升高(P<0.05)。结论:Survivin的异常表达与肺鳞癌的发生、发展密切相关,可能是影响肺癌预后的重要分子指标。
Objective： To investigate the expression of survivin gene in lung squamous carcinoma and study its clinical-pathological implication. Methods：The expression of survivin were detected by immunohistochemistry SP method in 35 cases of lung squamous carcinoma, 10 of normol lung tissue. Results ：71.4 percent （25 of 35） of cases had expression of survivin in the tumor cells, and 10.0 percent （ 1 of 10） of cases of the adjacent tissue it were present. There was a significant positive correlation between lung squamous carcinoma and normol tissue （P 〈 0.01 ）. Tumors with lymph node metastases （76.7%） had high survivin protein expression than those without metastasis（40.0% ） （P 〈 0.05 ）. Conclusion： Survivin gene play an important role in the occurrence and development of lung squamous carcinoma. It is suggested that survivin can be a useful marker for predicting invasion and metastasis ability of lung squamous carcinoma.
出处
《河南医学研究》
CAS
2009年第2期103-104,共2页
Henan Medical Research
