摘要
目的探讨建立阿霉素致兔早期心脏毒性模型的可行性并利用背向散射积分参数联合经胸超声心动图进行评估。方法10只兔每周静脉注射阿霉素2mg/kg,共为4周,同时选10只兔注射同等剂量生理盐水作为对照组。每周对二组兔心脏进行常规超声测量及进行背向散射积分参数测定。结果①常规超声参数阿霉素组与正常对照组无明显差别。②阿霉素组与正常对照组心肌IBS%呈周期性变化,第4周后心肌IBS%较正常对照组明显增高(P<0.05),第3周后CVIB明显减低(P<0.05)。③病理结果显示与人类阿霉素早期心脏毒性相似的改变。结论经静脉注射阿霉素可以形成早期心脏毒性模型,心肌背向散射积分技术联合经胸超声心动图可有效监测评估模型的建立和效果。
Objective To evaluate integrated backscatter （IBS） and transthoracic echocardiography in detecting early adriamycin-induced cardiotoxicity model in rabbits. Methods Ten rabbits were given 2 mg/kg body weight of adriamycin intravenously once a week for 4 weeks （group B）. Ten control rabbits received 2 ml/kg body weight of normal saline once a week for 4 weeks （group A）. IBS and conventional echographic parameters were obtained once a week in two groups at the same time, Results No significant difference of conventional echographic parameters was found between the two groups. IBS% changed periodically in group A and group B. After 4 weeks, IBS% in group B was significantly higher than in group＂ A; CVIB in group B was lower than that of group A after 3 weeks. In adriamycin-treated group, the characteristics for early adriamycin-induced cardiotoxicity in human patients were found. Conclusion Myocardial integrated backscatter is valuable to assess adriamycin-induced cardiomyopathy model in rabbits.
出处
《中国医学影像技术》
CSCD
北大核心
2006年第4期548-550,共3页
Chinese Journal of Medical Imaging Technology
