摘要
目的观察人子宫肌瘤及周围正常子宫平滑肌组织中IGF-1受体、雌、孕激素受体、PCNA及Bcl-2含量的区别,并分析其相互关系。方法用免疫组化ABC法检测子宫肌瘤及正常子宫平滑肌组织中IGF-1受体、雌、孕激素受体、PCNA及Bcl-2含量,并对其进行图像分析;用SPSS 11统计分析软件对其进行统计及相关性分析。结果子宫肌瘤组织中IGF-1受体的含量明显高于正常子宫平滑肌组织中含量,且与雌、孕激素受体、PCNA及Bcl-2之间均存在显著正相关。结论甾体激素可能通过调节生长因子IGF-1受体含量,调节与细胞增殖相关蛋白的表达以及抑制细胞凋亡等机制,来参与子宫肌瘤的发生发展。
Objective To observe the changes of IGF-1 receptors in uterine leiomyoma and its correlation with estrogen receptor, progesterone receptor, PCNA and Bel-2. Methods IGF-1 receptor, estrogen receptor, progesterone receptor, PCNA and Bel-2 were detected by immunohistochemieal ABC method. All the receptors were semi-quantified. The results were analyzed using SPSSll statistic software. Results The concentrations of IGF-1 receptor, estrogen receptor, progesterone receptor, PCNA and Bel-2 were all higher in the uterine leiomyoma than those in the peripheral muscle. There is a statistic positive correlation between them. Conclusion Estrogen and progesterone may stimulate uterine leiomyoma by regulating the contents of IGF-1 receptor, PCNA and Bel-2.
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2006年第2期144-147,共4页
Chinese Journal of Histochemistry and Cytochemistry
基金
上海市科技发展基金(98203)
关键词
子宫肌瘤
IGF-1受体
雌
孕激素受体
增殖细胞核抗原
BCL-2
Uterine leiomyoma
IGF-1 receptor
Estrogen receptor and progesterone receptor
Proliferating cell nuclear antigen
Bcl-2
