期刊文献+

阿托伐他汀治疗颈动脉粥样硬化疗效观察 被引量:1

暂未订购
导出
摘要 目的探讨阿托伐他汀对颈动脉粥样硬化的治疗作用。方法将80例颈动脉粥样硬化患者随机分为两组,分别予阿伐他汀口服及饮食控制,观察时间为6个月,治疗前后分别测量颈动脉IMT和斑块面积。结果治疗组中血脂降低水平同治疗前相比有显著性差异(P<0.05),软斑和混合斑的面积与治疗前相比明显减少(P<0.05),IMT在治疗后比治疗前有明显的减少(P<0.05);而对照组以上指标无明显的变化。结论阿托伐他汀对颈动脉粥样硬化有一定的治疗作用。
出处 《宁夏医学杂志》 CAS 2006年第4期286-287,共2页 Ningxia Medical Journal
  • 相关文献

参考文献7

二级参考文献28

  • 1郑世营,徐五音.卡托普利抗肺缺血再灌注损伤的实验研究[J].苏州医学院学报,1996,16(5):823-825. 被引量:1
  • 2[1]Ambrose JA, Martinez EE. A new paradigm for plaque stabilization. Circulation, 2002, 105 (16): 2 000-004
  • 3[2]Brasen JH, Harsch M, Niendorf A. Survival and cardiovascular pathology of hetero-zygous watanabe heritable hyperlipidaemic rabbits treated with pravastatin and probucol on a low-cholesterol(0.03%)-enriched diet. Virchows Arch, 1998, 432 (6): 557-562
  • 4[3]Brasen JH, Harsch M, Niendorf A. Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits. Virchows Arch, 1995, 426 (2):179-188
  • 5[4]Xu XP, Meisel SR, Ong JM. Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human moncyte-derived macrophages. Circulation, 1999, 99: 993-998
  • 6[6]Crisby M, Nordin-Fredriksson G, Shah PK. Pravastatin treatment increases collagen content and decreases lipid content, inflammation,metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation, 2001, 103: 926-933
  • 7[7]Libby P. What have we learned about the biology of atherosclerosis? The role of inflammation. Am J Cardiol, 2001, 88: 3J-6J
  • 8[8]Loftus IM, Naylor AR, Goodall S. Increased matrix metalloproteinase-9 activity in unstable carotid plaques. A potential role in acute plaque disruption. Stroke, 2000, 31 (1): 40-47
  • 9[10]Kanaki T, Saito Y. Anti-atherogenic drugs. Nippon Rinsho, 1998, 56 (10): 2 635-639
  • 10Chambless LE, Folsom AR, Clegg LX, et al. Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol, 2000, 151 (5): 478-487.

共引文献65

同被引文献30

  • 1罗助荣,盖晓波.不稳定性心绞痛患者调脂干预对颈动脉粥样硬化及C反应蛋白的影响[J].中华心血管病杂志,2004,32(11):977-980. 被引量:40
  • 2李翔,毕晓林,王正滨,隋忠国.立普妥治疗老年颈动脉粥样硬化疗效观察[J].山东医药,2006,46(8):36-37. 被引量:3
  • 3杨丽平,刘丽文,钱蕴秋,杨力军,李兰荪,何光彬,周晓东,沈敏.阿托伐他汀对冠心病患者颈动脉内-中膜厚度的影响[J].西北国防医学杂志,2007,28(2):104-106. 被引量:6
  • 4杨宝峰.药理学[M].第7版.北京:人民卫生出版社,2008:135-136.
  • 5陆再英,钟南山.内科学[M].第7版.北京:人民卫生出版社.2008:251.
  • 6Nissen SE,Tuzcu EM,Schoenhagen P,et al. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial[J]. JAMA,2004, 291 (9): 1071-80.
  • 7Vaughan CJ,Delanty N. Neuroprotective properties of statins in cerebral ischemia and stroke[J]. Stroke, 1999,30(9): 1969-73.
  • 8Schonbeck U,Gerdes N,Varo N,et al. Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells[J]. Circulation,2002,106(23):2888-93.
  • 9Motoyama K,Fukumoto S,Koyama H,et al. SREBP inhihits VEGF expression in human smooth muscle cells[J]. Biochem Biophys Res Commun,2006,342( 1):354-60.
  • 10Wong M,Edelstein J,Wollman J,et al. Ultrasonic-pathological comparison of the human arterial wall.Verification of intima-media thickness[J]. Arterioscler Thromb,1993,13(4):482-6.

引证文献1

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部