摘要
目的分析肾移植受者环孢素A(CsA)血药浓度监测情况. 方法采用荧光偏振免疫分析法(FPIA法)测定51例患者术后CsA谷浓度,并对其首次CsA谷浓度监测时间、CsA谷浓度及监测规律性的影响进行统计分析.结果 70.59%的患者在服药后3～10 d内进行了血药浓度监测,68.69%的患者CsA谷浓度在150～400 μg*L-1之间,规律组CsA谷浓度CV明显小于非规律组(t=7.97,P<0.01).结论我院肾移植受者CsA血药浓度监测基本合理,规律性监测的患者其CsA血药浓度比非规律性监测的更平稳.
Objective： To analyze the situation of cyclosporine A blood concentration monitoring in renal transplantation recipients. Methods. cyclosporine A blood concentration in 51 cases of renal transplantation recipients were measured by means of fluorescence polarization immunoassay （FPIA）, and the first monitoring time of CsA blood concentration, CsA blood concentration, the influence of monitoring rule were analyzed. Results： The blood concentration of 70.59% renal transplantation recipients were measured within 3-10 days after administration, the CsA blood concentration of 68. 69% cases was between 150-400μg.L^-1, and the coefficient of variation of CsA blood concentration in＂ rule group＂ was smaller than that in ＂non- rule group＂ （ P 〈 0.01 ）. Conclusion： The situation of CsA blood concentration monitoring in renal transplantation recipients in our hospital is rational, CsA blood concentration in＂ role group＂ is more stable than that in ＂non- rule group＂.
出处
《泰山医学院学报》
CAS
2005年第4期308-309,共2页
Journal of Taishan Medical College
关键词
肾移植
环孢素A
血药浓度
监测
renal transplantation cyclosporine A
blood concentration
monitoring
