摘要
目的：观察艾司氟比洛芬凝胶的抗炎镇痛作用。方法：采用二甲苯诱导小鼠耳肿胀,用棉球诱导大鼠肉芽肿,观察艾司氟比洛芬凝胶的抗炎作用；用热板法和扭体法观察艾司氟比洛芬凝胶对小鼠和大鼠的镇痛作用。双氯芬酸乳胶剂(1%)作为阳性对照药,以2%,1.5%和1%的艾司氟比洛芬凝胶分组给药。结果：2%和1.5%艾司氟比洛芬凝胶对二甲苯引起的小鼠耳肿胀有较好的抑制作用(P＜0.01),在给药后30,45 min均能明显提高热板法小鼠的痛阈,改善痛阈提高百分率(P＜0.01,P＜0.05)。2%,1.5%和1%艾司氟比洛芬凝胶对大鼠棉球肉芽肿的形成有一定的抑制作用(P＜0.01)；对1%醋酸引起的大鼠痛反应有较好的抑制作用(P＜0.01)。结论：艾司氟比洛芬凝胶对大鼠及小鼠的炎症及痛反应模型均有抑制作用。
AIM： To study the anti-inflammatory and analgesic effect of esflurbiprofen gel. METHODS： Animal models of acute and subacute inflammations （granuloma） were induced respectively by dimethyl benzene in mice and cotton ball in rats to observe the anti-inflammation effect of esflurbiprofen gel, while hot-plate test and writhing test were adopted to study the analgesic effect of esflurbiprofen gel. Animals were grouped according to the administration of 2 %, 1.5 % and 1% esflurbiprofen gel,with diclofenac emulsion （1% ）taken as positive control. RESULTS： In mice, 2 % and 1.5 % esflurbiprofen gel could reduce ear edema（P 〈 0.01） and elevate percentage of pain threshold for hot-plate test at 30,45 min after drug administration （P 〈 0.01 ,P 〈 0.05）. 2 %, 1.5 % and 1% esflurbiprofen gel could suppress granuloma（P 〈 0.01 ）, alleviate the pain caused by acetic acid in rats（P 〈 0.01）. CONCLUSION： Esflurbiprofen gel possesses obvious anti-inflammatory and analgesic effects.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2006年第4期266-269,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
氟比洛芬
双氯芬酸
消炎药
非甾类
镇痛
投药
皮肤
艾司氟比洛芬凝胶
flurbiprofen
diclofenac
anti-inflammatory agents,non-steroidal
analgesia
administration,cutaneous
esflurbiprofen gel
