摘要
蛙皮多肽抗生素(peptide antibiotics)是由两栖动物皮肤分泌的,有抗菌、抗癌作用的多肽,广泛存在于两栖动物的皮肤分泌物中.由于具有抗菌谱广、种类多、不易产生耐药性等优点,其应用已涉及到医药工业、食品工业等领域,应用前景广阔.从蛙皮多肽抗生素的分类、分子结构与功能、作用机制、生物学活性、化学修饰和基因工程方面概述了其研究现状与进展.
The peptide antibiotics of amphibian skin are secreted by amphibian skin. They possess the function of antimicrobic and anticancer. Due to the advantage of broad-spectrum antimicrobial function, various kinds, so on, they have been used in medical, food industry etc. and have great potential in those fields. The recent research progress in the peptide antibiotics from amphibian skin, including their classification, molecular structure, mechanism of action, biological activity, chemical modifica- tion and genetic engineering, was reviewed in this paper.
出处
《成都大学学报（自然科学版）》
2006年第1期25-30,44,共7页
Journal of Chengdu University（Natural Science Edition）
基金
四川省教育厅重点科研项目(2003A201)
关键词
多肽抗生素
两栖动物
化学修饰
进展
peptide antibiotics
amphibian
chemical modification
progress
