摘要
以天然抗菌肽结构为蓝本进行设计合成的多肽抗生素,为新型抗生素的研制提供了新的途径。本文对近年来人工化学合成的多肽抗生素的序列组成、结构特点、生物活性、作用机制以及设计合成等方面进行了综述,为新型多肽抗生素作为候选药物的设计和筛选提供参考。
The novel design of synthetic polypeptide antibiotics, which based on the structure of the natural antimicrobial peptides, provided a new way for antibiotic agents development. This paper reviewed the latest achievements in artificial synthetic polypeptide antibiotics, including their sequence compositions, structure characteristics, biological activities, mechanisms of action, and the synthesis methods etc, which may be expected to serve as references for designing and screening attractive candidates for antimicrobial drug.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2012年第3期184-189,共6页
Chinese Journal of Antibiotics
基金
辽宁省教育厅科学技术研究项目(No.2009A413)
大连市科学技术基金项目(No.2008J22JH010)
关键词
化学合成
多肽
抗生素
抗菌活性
Artificial synthesis
Polypeptide
Antibiotic
Antibacterial activity
