摘要
目的探讨老年高血压患者颈动脉病变与血浆内皮素-1(ET-1)、脂蛋白(a)[Lp(a)]的关系。方法对120例老年高血压患者进行颈动脉超声检查。根据病变的不同分为颈动脉无斑块(NCP)组、硬斑块(HCP)组、软斑块(SCP)组,并测定上述患者ET-1,血清Lp(a)的含量。结果颈动脉有斑块(CP)组与NCP组比较,ET-1及Lp(a)含量明显增高(P<0.01),SCP组与HCP组比较Lp(a)含量明显增高(P<0.01)。结论老年高血压患者颈动脉斑块的形成与血管内皮损伤、Lp(a)代谢异常有明显关系。
Objective To explore the relationship between endothelins and lipoprotein （a） [ Lp （a） ] in elderly hypertensive patients with carotid artery atherosclerosis. Methods 120 elderly hypertensive patients were divided into four groups based on the result of carotid artery uhrasonography ： non-plaque group （43 cases） , hard plaque group （31 cases） and soft plaque group （46 cases）. Endothelin-1 （ET-1） and Lp（a） were determined in these patients. Results Compared with non-plaque groups, plaque group had higher levels of ET-1 and Lp（a）. The difference was significant（ P 〈 0. 01 ） . Compared with hard plaque group, soft plaque group had higher level of Lp （a） （ P 〈 0. 01 ）. Conclusions There is a significant association between the formation of carotid atherosclerotic lesions and hypertension injury and disorders of lipids metabolism.
出处
《实用老年医学》
CAS
2006年第2期121-122,共2页
Practical Geriatrics
