摘要
目的:观察健康成年人性活动后血浆内皮素水平的变化。方法:选择2004-06/08来自北京市石景山区某社区自愿参加本实验的成年已婚者共46人为观察对象,经实验前教育详细讲解实验流程、要求和实验目的,以及性活动的性欲期、高潮期的界定,签署知情同意书,仔细询问病史初选观察对象,在进行必要的体格检查和实验室检查后进一步筛选,最终选择26人符合条件的观察对象纳入实验。2人因实验资料不全而被剔除,最后实际观察对象24人。男女各12人,分男女2组,每组12人。观察对象在自己家中惯常的条件下进行男上位的性活动,现场采集其性活动前基线状态及性活动高潮期后10min内、30min、60min的肘静脉血,以放射免疫法检测其血浆内皮素水平,以配对t检验分析性活动后内皮素梯度变化,t检验行性别组间对比。结果:46人中最终进入结果分析24人。①女性组只在性高潮后30min血浆内皮素水平较基线状态显著性下降犤(31.139±10.185),(39.790±12.250)ng/L,t=2.254,P<0.05犦。②男性组性活动后各时段10min内、30min、60min血浆内皮素水平与基线状态比较无显著性变化犤(35.872±15.195),(41.024±15.846),(39.812±22.630),(36.755±9.777)ng/L,P>0.05犦。③男女性别组间基线状态,性高潮后10min内,性高潮后30min,性高潮后60min各时段血浆内皮素水平差异均不显著。结论:性活动相伴的血浆内皮素变化应引起血管先反应性舒张继而收缩的效应,这个过程男性持续时间较短、恢复较快,而女性持续时间较长、恢复较慢。除女性在性高潮后30min时血浆内皮素水平较基线状态有显著性下降外,健康成年男女在性活动后血浆内皮素水平的无显著性梯度变化;男女性别组间未发现显著性差异。
AIM： To observe the changes of plasma endothelin （ET） after sexual activity in healthy adults. METHODS： Forty-six married adults in a community of Beijing Shijingshan district were voluntarily involved in the study from June to August 2004. Before the study, the procedure, request and objective of the study, the definition of phases off sexuality and sexual orgasm were explained in details, and all the subjects signed the consent for knowledge of the condition. The subjects were preliminarily selected after careful demand of disease history, and they were further screened after necessary physical examination and laboratory examination. Finally 26 cases met the inclusion criteria were involved in the analysis, and 2 with incomplete data were deleted, finally 24 cases （12 males and 12 females） were observed. Intercourse was carried out as their regular condition with missionary position at their own home. Venous blood sample from elbow was collected at baseline condition （pre-sexual activity） and 10, 30 and 60 minutes postorgasm respectively, and the plasma level of endothelin was measured with radioimmunoassay. The gradient changes of endothelin were analyzed with the paired t test and the differences between male and female .groups were analyzed with the t lest. RESULTS： Of the 46 cases, 24 were involved in the analysis of results. ①Compared with baseline status, the plasma level of endothelin in the female group only significantly decreased at 30 minutes after sexual orgasm [（31.139±10.185）, （39.790±12.250） ng/L, t=2.254, P 〈 0.05]. ②In the male group, there was insignificant differences in the plasma level of endothelin within 10 minutes and at 30 and 60 minutes after sexual activity as compared with thai of baseline status [（35.872 ±15.195）, （41.024±15.846）, （39.812±22.630）, （36.755±9.777） ng/L, P 〉 0.05]. ③There were no significant differences in the plasma level of endothelin between the male and female groups at baseline status and within 10 minutes and at 30 and 60 minutes after sexual orgasm. CONCLUSION： Sexual activity accompanied changes of plasma level of endothelin can result in the vascular diastole first and then systole reactions, which lasts for a shorter period, and recovers faster in males but lasts for a longer period and recovers slower in females. Except that the plasma level of endothelin is significantly decreased at 30 minutes after sexual orgasm as cmnpared with the baseline status in females, there are insignificant gradient changes in the plasma level of endothelin after sexual activity between healthy adult males and females.No significant differences are observed between male and female groups.
出处
《中国临床康复》
CAS
CSCD
北大核心
2005年第24期157-159,共3页
Chinese Journal of Clinical Rehabilitation
基金
首都医学科研发展基金(TS1998-09)
清华大学第二附属医院科研基金资助项目~~
