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晚发性老年性痴呆相关基因的研究 被引量：2

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作者 王时光 杨文明
机构地区 安徽省中医院神经内科
出处 《临床荟萃》 CAS 北大核心 2006年第7期519-521,共3页 Clinical Focus
基金 安徽省教育委员会自然科学研究项目(99JLZX0138) 安徽省人才开发基金资助(2003Z-026) 安徽省自然科学基金资助(99044591)
关键词 阿尔茨海默病 基因 多态性 单核苷酸
分类号 R749 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献20

  • 1Metzger RE,Ladu MI,Pan JB,et al.Neurons of the human frontal cortex display apolipoprotein E immunoreactivity:implications for Alzheimer's disease[J].J Neuropathol Exp Neurol,1996,55(3):372-380.
  • 2Lindsay J,Laurin D,Verreault R,et al.Risk factors for Alzheimer's disease:a prospective analysis from the Canadian Study of Health and Aging[J].Am J Epidemiol,2002,156(5):445-453.
  • 3Kivipelto M,Helkala EL,Laakso MP,et al.Apolipoprotein E epsilon4 allele,elevated midlife total cholesterol level,and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease[J].Ann Intern Med,2002,137(3):149-155.
  • 4Josephs KA,Tsuboi Y,Cookson N,et al.Apolipoprotein E epsilon 4 is a determinant for Alzheimer-type pathologic features in tauopathies,synucleinopathies,and frontotemporal degeneration[J].Arch Neurol,2004,61(10):1579-1584.
  • 5Kamboh MI,Sanghera DK,Ferrell RE,et al.APOE·4associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism[J].Nat Genet,1995,10(4):486-488.
  • 6廖伟娇,陈盛强,陈柏铭,刘忠民,刘利东.α_1-抗糜蛋白酶基因多态性与阿尔茨海默病相关性探讨[J].广州医药,2003,34(4):57-59. 被引量：1
  • 7Blacker D,Wilcox MA,Laird NM,et al.Alpha-2 macroglobulin is genetically associated with Alzheimer disease[J].Nat Genet,1998,19(4):357-360.
  • 8Saunders AJ,Bertram L,Mullin K,et al.Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2 macroglobuln[J].Hum Mol Genet,2003,12(21):2765-2776.
  • 9毕胜,王德生,张昱,吴江,盛雨辰,韩辉,王守春,孔繁军.低密度脂蛋白受体相关蛋白基因两种多态性与阿尔茨海默病的关系[J].中华神经科杂志,2000,33(1):10-13. 被引量：7
  • 10Kolsch H,Ptok U,Mohamed I,et al.Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer's disease[J].Am J Med Genet B Neuropsychiatr Genet,2003,121(1):128-130.

二级参考文献20

  • 1彭天鉴 译.美国精神疾病分类与诊断标准:第4版（DSM－Ⅳ）[M].,2001.68-77.
  • 2[1]Bertram L, Blacker D, Mullin K, et al. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science, 2000, 290(5500): 2302～2303.
  • 3[2]Ertekin Taner N,Graff Radford N, Younkin LH, et al. Linkage of plasma A?42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science, 2000, 290(5500): 2303～2304.
  • 4[3]Myers A, Holmans P, Marshall H, et al. Susceptibility locus for Alzheimer's disease on chromosome 10. Science, 2000,290(5500):2304～2305.
  • 5[4]Corder EH, Saunders AM. Strittmatter WJ, et al. Gene dose of apolipoprptein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 1993,261(5123): 921～923.
  • 6[5]Kehoe P, Wavrant-De VF, Crook R, et al. A full genome scan for late onset Alzheimer's disease. Human Molecular Genetics, 1999, 8(2): 237～245.
  • 7[6]Abraham R, Myers A, Wavrant-DeVrieze F, et al. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics, 2001,109(6): 646～652.
  • 8[7]McDermott JR, Gibson AM. Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidase: involvement of insulin-degrading enzyme. Neurochemical research, 1997, 22(1): 49～56.
  • 9[8]Vekrellis K, Ye Z, Qiu WQ, et al. Neurons regulate extracelluar levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. Neuroscience, 2000,20(5): 1657～1665.
  • 10[9]Li YJ, Scott WK, Hedges DJ, et al. Age at onset in two common neurodegenerative disease is genetically controlled. American Journal of Human genetics, 2002, 70(4): 985～993.

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临床荟萃
2006年 第7期

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