1Schmidtke K,Hull M.Cerebral small vessel disease:how does it pro-gress?.J Neurol Sci,2005,229-230:13-20.
2Lesnik Oberstein SA,Haan J.Cerebral autosomal dominant arteriopa thy with subcortical infarcts and leukoencephalopathy (CADASIL).Panminerva Med,2004,46:265-276.
3Hund-Georgiadis M,Norris DG,Guthke T,et al.Characterization of cerebral small vessel disease by proton spectroscopy and morphological magnetic resonance.Cerebrovasc Dis,2001,12:82-90.
4DeMattos RB,Bales KR,Cummins DJ,et al.Brain to plasma amy-loidbeta efflux:a measure of brain amyloid burden in a mouse model of Alzheimer's disease.Science,2002,295:2264-2267.
5Cirrito JR,May PC,O Dell MA,et al.In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life.J Neurosci,2003,23:8844-8853.
6Kawarabayashi T,Younkin LH,Saido TC,et al.Age-dependent changes in brain,CSF,and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.J Neurosci,2001,21:372-381.
7Kuo YM,Emmerling MR,Lampert HC,et al.High levels of circulating Abeta42 are sequestered by plasma proteins in Alzheimer's disease.Biochem Biophys Res Commun,1999,257:787-791.
8Matsubara E,Ghiso J,Frangione B,et al.Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Downs syndrome.Ann Neurol,1999,45:537-541.
9Holtzman DM.Potential role of endogenous and exogenous amyloidbeta binding molecules in the pathogenesis,diagnosis,and treatment of Alzheimer disease.Alzheimer Dis Assoc Disord,2003,17:151-153.
10Shibata M,Yamada S,Kumar SR,et al.Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.J Clin Invest,2000,106:1489-1499.
4Bronge L,Bogdanovic N,Wahlund LO.Postmortem MRI and histopathology of white matter changes in Alzheimer brains:A quantitative,comparative study.Dement Geriatr Cogn Disord,2002,13:205-212.
5Han X,Holtzman M,McKeel DW,et al.Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease:potential role in disease pathogenesis.J Neurochem,2002,82:809-818.
6Bozzali M,Falini A,Franceschi M,et al.White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging.J Neurol Neurosurg Psychiatry,2002,72:742-746.
7Rose SE,Chen F,Chalk JB,et al.Loss of connectivity in Alzheimer's disease:an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging.J Neurol Neurosurg Psychiatry,2000,69:528-530.
8Choi SJ,Lim KO,Monteiro I,et al.Diffusion tensor imaging of frontal white matter microstructure in early Alzheimer's disease:a preliminary study.J Geriatr Psychiatry Neurol,2005,18:12-19.
9Pearson RC,Esiri MM,Hiorns RW,et al.Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.Proc Natl Acad Sci USA,1985,82:4531-4534.
10Rogers J,Morrison JH.Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease.J Neurosci,1985,5:2801-2808.
4Jellinger KA. Alzheimer disease and cerebrovascuIar pathology: an update [ J ]. J Neura J Transm, 2002, 109 (5-6): 813-836.
5Wang T, Baron M, Trump D. An overview of Notch3 function in vascular smooth muscle cells [ J ]. Prog Biophys Mol Bi01, 2008, 96 (1 -3): 499-509.
6Peter N, Opherk, C, Danek A, et al. The pattern of cognitive performance in CADASIL: a monogenic conditiou leading to subcotical isehemic vascular dementia [J]. Am J Psychiatry, 2005, 162 (11): 2078 - 2085.
7Yanagawa S, Ito N, Arima K, et al. Cerebral auto- somal recessive arteriopathy with subcortical infarcts and leukoencephalopatby [J]. Neurology, 2002, 58 (5): 817 -820.
8Andin U, Gustafson L, Passant U, et al. A clinico - pathological study of heart and brain lesion in vascu- lar dementia [J]. Dement Geriatr Disord, 2005, 19 (4) : 222-228.
9Graham NL, Emery T, Hodges JR. Distinctive cognitive profiles in Alzheimer' s disease and subcortical vascual dementia [ J ]. try, 2004, 75 (1): 61 J Neurol Neurogurg Psychiatry, 2004, 75 (1): 61-71.
10Prins ND, van Dijk EJ, den Heijer T, et al. Cerebral small vessel disease and decline in information processing speed, executive function and memory [J]. Brain, 2005, 128 (9): 2034-2041.