摘要
目的调查福建汉族人群HLA-DRB1等位基因的多态性。方法应用寡核苷酸基因芯片分型技术对福建地区620名汉族人群进行HLA-DRB1位点的基因分型。结果在HLA-DRB1位点共检出了14种等位基因,基因频率较高的依次为DRB1*09、12、15、04、08。结论福建汉族HLA-DRB1等位基因多态性与南方汉族人群相近,但也有其独特的特点。
Objective To investigate the HLA-DRB1 allele polymorphism in Fujian Han nationality population. Methods Six hundred and twenty individual samples collected from unrelated Fujian Han population were subjected to genotyping using oligonucleotide microarray technique. And the allele frequencies of HLA-DRB1 were calculated and compared with other populations. Results Fourteen HLA-DRB1 alleles of Fujian Han population were detected. The gene frequencies ordered from high to low were HLA-DRB1 ＊ 9, 12, 15, 4, 8 respectively. Condtision The HLA-DRB1 distribution of Fujian Han population shares some genetic characters with southern Chinese Han populations, but these characters differ from northern Chinese populations.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2006年第2期240-241,共2页
Chinese Journal of Medical Genetics
基金
全军"十五"课题-医学杰出人才基金(01J003)
上海市科委重大课题(024919005)~~
